穴位贴敷联合口服中药治疗痛经的临床效果

Clinical effect of point application combined with oral Chinese medicine in the treatment of dysmenorrhea

目的探究穴位贴敷联合口服中药治疗痛经的临床效果。方法选取2018年3月~2019年12月南昌大学第一附属医院诊治的93例痛经患者,按随机数字表法分为对照组(n=46)和观察组(n=47)。对照组给予口服中药少腹逐瘀汤治疗,观察组给予穴位贴敷(自制痛经贴)联合口服中药少腹逐瘀汤治疗,比较两组的治疗效果、前列腺素和疼痛程度。结果观察组的疗效优于对照组,差异有统计学意义(P<0.05);治疗后,外周血前列腺素F2α(PGF2α)、外周血F2α/和前列腺素E2的比值(PGF2α/PGE2)低于对照组,前列腺素E2(PGE2)高于对照组,差异有统计学意义(P<0.05);治疗后,观察组的视觉模拟量表评分低于对照组,差异有统计学意义(P<0.05)。结论穴位贴敷联合口服中药治疗可降低痛经患者的疼痛程度,对患者前列腺素的合成具有良性调节作用,提高治疗效果。

Objective To investigate the clinical effect of point application combined with oral Chinese medicine in the treatment of dysmenorrhea.Methods A total of 93 patients with dysmenorrhea who were treated from March 2018 to December 2019 in the First Affiliated Hospital of Nanchang University were selected and divided into control group(n=46)and observation group(n=47)according to the random number table method.The control group was given oral Shaofu Zhuyu Decoction,while observation group was treated with point application(self-made dysmenorrhea paste)combined with oral Shaofu Zhuyu Decoction.The curative effect,prostaglandin and degree of pain were compared between the two groups.Results The efficacy of observation group was better than that of control group,the difference was statistically significant(P<0.05).The peripheral prostaglandin F2α(PGF2α)and peripheral prostaglandin F2α/prostaglandin E2(PGF2α/PGE2)in observation group were lower than those in control group,while the PGE2 in the observation group was higher than that in control group(P<0.05).The score of visual analogue scale in observation group was lower than that in control group after treatment,the difference was statistically significant(P<0.05).Conclusion Point application combined with oral Chinese medicine in the treatment of dysmenorrhea can decrease the degree of pain,have benign regulative effect on the synthesis of prostaglandin,and increase curative effects.