硫酸镁、硝苯地平联合拉贝洛尔治疗妊娠期高血压的效果

Effect of Magnesium Sulfate,Nifedipine plus Labetalol in treating pregnancy-induced hypertension patients

目的探究硫酸镁、硝苯地平联合拉贝洛尔治疗妊娠期高血压(PIH)的效果。方法选取2019年1~10月我院收治的87例PIH患者作为研究对象,按照数字排列法分为参照组(n=43)与研究组(n=44)。参照组采用硫酸镁、硝苯地平治疗,研究组加服拉贝洛尔,比较两组的临床疗效、血流动力学、尿液蛋白质情况。结果研究组的临床总有效率为93.18%,高于参照组的81.40%,差异有统计学意义(P<0.05);治疗后,研究组的血黏度、红细胞比容低于参照组,差异有统计学意义(P<0.05);治疗后,研究组的24 h尿蛋白、尿钙黏蛋白、尿激肽原水平低于参照组,差异有统计学意义(P<0.05)。结论PIH应用硫酸镁、硝苯地平、拉贝洛尔联合治疗能显著降低患者的血黏度及红细胞比容,改善患者24 h蛋白尿定量,提高临床治疗效果。

Objective To explore the effect of Magnesium Sulfate,Nifedipine plus Labetalol in treating pregnancy-induced hypertension(PIH)patients.Methods A total of 87 PIH patients treated from January to October 2019 in our hospital were selected.According to random number table,patients were divided into reference group(n=43)and research group(n=44).The reference group took Magnesium Sulfate and Nifedipine;the research group took Magnesium Sulfate,Nifedipine combined with Labetalol.Clinical efficacy,hemodynamics and urine protein changes for two groups were compared.Results The total clinical effective rate in the research group(93.18%)was higher than that in the reference group(81.40%),with statistical difference(P<0.05);after treatment,blood viscosity and erythrocyte ratio in the research group were lower than those in the reference group,with statistical differences(P<0.05);after treatment,24 h urine protein,mucoprotein and human urinary kallidinogenase levels in the research group were lower than those in the reference group,with statistical differences(P<0.05).Conclusion Magnesium Sulfate,Nifedipine combined with Labetalol can remarkably reduce the blood viscosity and erythrocyte ratio,improve 24 h urine protein quantitation and increase therapeutic effects.