溃疡性结肠炎患者血浆sIL-2R、MUC1检测及其意义

Detection and significance of plasma sIL-2R and MUC1 in patients with ulcerative colitis

目的:分析溃疡性结肠炎患者血浆可溶性白细胞介素-2受体(sIL-2R)、上皮细胞膜结合黏液素1(MUC1)检测的意义。方法:检测溃疡性结肠炎患者(研究组)及体检健康者(对照组)血浆sIL-2R、MUC1水平。对比分析研究组轻、中、重度及活动期、缓解期患者各指标水平,另外比较活动期预后良好与预后不良患者各指标水平,采用受试者工作特征(ROC)曲线评估血浆sIL-2R、MUC1水平检测对活动期患者预后的预测价值。结果:研究组sIL-2R、MUC1水平[(354.71±11.26)、(11.93±2.38)U/mL]高于对照组[(91.65±8.32)、(6.84±1.52)U/mL](t=158.329、15.038,均P=0.000),研究组活动期sIL-2R、MUC1水平[(390.72±11.63)、(14.85±3.06)U/mL]高于缓解期[(287.34±9.25)、(6.47±1.04)U/mL](t=42.754、14.765,均P=0.000),研究组预后良好者sIL-2R、MUC1水平[(365.71±10.48)、(13.43±2.16)U/mL]低于预后不良者[(477.29±11.73)、(19.77±1.94)U/mL](t=32.933、9.521,均P=0.000),sIL-2R、MUC1水平在轻、中、重度患者中依次升高(F=627.902、67.224,均P<0.05);二者单项及联合检测的灵敏度76.92%、84.62%、76.92%,特异度80.00%、77.78%、86.67%。结论:溃疡性结肠炎患者血浆sIL-2R、MUC1水平升高,与病情程度、活动性相关,可预测预后。

Objective: To analyze the significance of detection of plasma soluble interleukin-2 receptor(sIL-2 R) and membrane-bound mucin-1 of epithelial cells(MUC1) levels in patients with ulcerative colitis. Methods: The levels of s IL-2 R and MUC1 in ulcerative colitis patients(study group) and healthy people(control group) were measured. The indicators of mild, moderate and severe patients of study group and in active and remission patients were compared and analyzed, and the levels of indexes between the patients with good prognosis and the patients with poor prognosis in the active period were compared, then the prediction values of sIL-2 R and MUC1 levels in the prognosis of patients with active stage were evaluated by receiver operator characteristic(ROC) curve. Results: The levels of sIL-2 R and MUC1 in study group [(354.71 ± 11.26),(11.93 ± 2.38) U/mL] were higher than those in control group[(91.65±8.32),(6.84±1.52) U/mL](t = 158.329, 15.038, all P = 0.000), and the levels of sIL-2 R and MUC1 in active phase of study group [(390.72±11.63),(14.85±3.06) U/mL ]were higher than those in remission stage[(287.34±9.25),(6.47±1.04) U/mL](t = 42.754, 14.765, all P = 0.000), and levels of sIL-2 R and MUC1 in the good prognosis patients of study group [(365.71±10.48),(13.43±2.16) U/mL]were lower than those in the poor prognosis patients[(477.29±11.73),(19.77±1.94) U/mL ](t=32.933, 9.521, all P = 0.000),and the levels of sIL-2 R and MUC1 in mild, moderate and severe patients were increased in turn(F=627.902,67.224, all P< 0.05). The sensitivity of the two indexes single and combined detection in predicting the prognosis were 76.92%, 84.62%, 76.92% and the specificity were 80.00%, 77.78%, 86.67%. Conclusion: The plasma levels of sIL-2 R and MUC1 in patients with ulcerative colitis are high, which are related to the severity and activity of the disease, and can predict the prognosis.