高血压与非酒精性脂肪性肝病的关系

Association between hypertension and nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)与高血压同为代谢综合征的重要组成部分,二者之间有很强的关联性。通过临床数据分析了NAFLD与高血压之间的联系。简述了二者之间相互影响的共同可能机制。其中,胰岛素抵抗、肠道菌群、肾素-血管紧张素-醛固酮系统在二者的发病机制中起着重要的作用。同时也总结了肾素-血管紧张素-醛固酮系统抑制药以及利尿剂在NAFLD治疗中的应用,为今后进一步明确二者之间的关系,深入了解二者相互影响的机制以及NAFLD合并高血压的治疗提供参考。

Nonalcoholic fatty liver disease(NAFLD)and hypertension are both important components of metabolic syndrome,and there is a strong association between these two diseases.This article analyzes the association between NAFLD and hypertension based on clinical data and describes the common pathogeneses of the two diseases,among which insulin resistance,gut microbiota,renin-angiotensin-aldosterone system play an important role in the pathogenesis of these two diseases.In addition,this article briefly summarizes the application of renin-angiotensin-aldosterone system inhibitors and diuretics in the treatment of NAFLD,which provides a reference for further clarifying the association between these two diseases,understanding the mechanism of interaction between the two diseases,and exploring the treatment methods for NAFLD with hypertension.