饮酒对非酒精性脂肪性肝病的影响

Influence of drinking on nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)定义为不存在大量饮酒(饮酒量被限定为安全阈值内)的情况下发生的肝脏脂肪变性,与酒精性肝病的区别很大程度上取决于饮酒量。饮酒与NAFLD在一定比例人群中共存,这一比例正在持续增加。关于饮酒"安全阈值"的界定、在"安全阈值内"的适度饮酒对于NAFLD是否具有保护作用,从而改善慢性肝病的不良结局和生存预后,目前尚存争议。针对上述观点进行了分析阐述,并认为在评估饮酒对NAFLD的影响时,重点应当关注个体化风险评估,判断利弊和饮酒建议均应遵循个体化原则。

Nonalcoholic fatty liver disease(NAFLD)is defined as hepatic steatosis without heavy drinking(the amount of alcohol intake is limited within the safe threshold),and the difference between NAFLD and alcoholic liver disease is largely dependent on the amount of alcohol intake.Alcohol intake and NAFLD coexist in a considerable proportion of the population,and this proportion is increasing continuously.There are still controversies over the definition of“safe threshold”and whether moderate drinking within the“safe threshold”has a protective effect against NAFLD,so as to improve the adverse outcome and survival prognosis of chronic liver diseases.This article elaborates on the above ideas,and it is believed that we should pay attention to individualized risk assessment when evaluating the influence of drinking on NAFLD and follow the principle of individualization when judging the benefits and harms of drinking and giving suggestions for drinking.