摘要
生脉注射液(Shengmai Injection,SMI)是由红参、麦冬和五味子3味中药组成的中药复方制剂,在临床上除了广泛用于治疗心血管系统疾病外,还用于抗肺病、癌症化疗等的辅助治疗。近年来,SMI的临床前基础研究日渐广泛,主要包括SMI的化学成分、体内过程和作用机制等,为揭示该方的药效物质基础提供了一定的科学依据。综述了该方的物质组成、临床前药动学和药效学研究,以期为SMI的质量控制、产品二次开发和临床合理应用提供参考。
Shengmai Injection(SMI),is a traditional Chinese medicine(TCM)formula injection composed of Panax ginseng,Ophiopogon japonicas and Schisandra chinensis,which is widely used in clinic for the treatment of cardiovascular diseases as well as protecting against pulmonary disease and add-on therapy to cancer chemotherapy.In recent years,the pre-clinical basic research of SMI was widely performed.The studies,including chemical composition,in vivo process,and action mechanism and so on of SMI,helped to provide scientific foundation for revealing the material basis of formula.In this paper,the studies on material composition,pre-clinical pharmacokinetics and pharmacodynamics of this formula were summarized,so as to provide reference for the quality control,second development and rational clinical application of SMI.
作者
郑博鸿
詹淑玉
周鸿宇
冯一涵
方梦婷
郑永霞
刘国强
李明娟
ZHENG Bo-hong;ZHAN Shu-yu;ZHOU Hong-yu;FENG Yi-han;FANG Meng-ting;ZHENG Yong-xia;LIU Guo-qiang;LI Ming-juan(Medical College of Jiaxing University,Jiaxing 314001,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第20期5360-5371,共12页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81503338)
浙江省自然科学基金资助项目(LY18H280011)
浙江省大学生科技创新活动计划(新苗人才计划)项目(2019R417026)
嘉兴学院B类重点建设学科(药学)
嘉兴学院重点SRT资助项目。
关键词
生脉注射液
中药复方
物质组成
药动学
药效学
Shengmai Injection
TCM formula
material composition
pharmacokinetics
pharmacodynamics