植物次生代谢物转运蛋白研究进展

Recent advances for plant secondary metabolite transporters

植物在生命活动中产生一系列的次生代谢物,这些化合物在植物细胞内产生后,将转运至特定细胞器进行储存,或被分泌到细胞外。转运蛋白是一类膜蛋白,可介导生物膜内外化学物质的跨膜转运及信号交换,在植物次生代谢物的跨膜运输过程中发挥重要作用。阐明植物次生代谢物转运蛋白的转运功能,有助于解析次生代谢物生物合成及利用途径的分子机制,为开展药用植物活性次生代谢物的合成生物学研究提供重要元件。详细介绍了转运蛋白的结构与分类,综述了近年来植物次生代谢物转运蛋白的研究进展,总结了转运蛋白功能验证的研究方法,为药用植物次生代谢物的生物合成途径解析及开发利用提供参考。

Plants produce a series of secondary metabolites in cells. These secondary metabolites will be transported to specific organelles for storage or secreted extracellularly. Transporters are a class of membrane proteins that mediate transmembrane transport of chemicals and intracellular signal exchange, and also play an important role in transmembrane transport of plant secondary metabolites. Identification of the function of the secondary metabolite transporters of medicinal plants will help to elucidate the biosynthetic pathways of secondary metabolites in medicinal plants and the molecular mechanism of the transport process of bioactive compounds. In this review, the structure and classification of plant transporters are described in detail. The research progress of plant secondary metabolic transporters and the methods for functional verification of transporter, which have been summarized in this article, will provide a basis for elucidating the biosynthetic pathways and utilization of secondary metabolites in medicinal plants.