性传播感染的化学预防

Chemoprophylaxis in sexually transmitted infections

高危人群中性传播感染(STI)的发病率逐年上升。鉴于HIV暴露前后预防的成功经验,化学预防STI传播是安全、有效的防治手段。在男男性行为人群中开展的研究结果显示,无论是暴露前还是暴露后,多西环素均能有效降低STI发病率。本文通过对STI化学预防研究进展进行综述,为化学预防的实施提供科学依据。

The incidence of sexually transmitted infections(STI)in high-risk population is accelerating in the recent years.Considering the success in the HIV pre-exposure prophylaxis(Prep)or post-exposure prophylaxis(Pep),the chemoprophylaxis is a safe and effective method to control the prevalence of STI.Based on the results in men who have sex with men(MSM),the doxycycline can reduce the incidence of STI in Prep or Pep users.The current researches on the chemoprophylaxis in STI are reviewed in this article,so as to promote some effective suggestions for the future researches in chemoprophylaxis.