基于生物电阻抗技术的乳腺癌患者人体成分研究

Study on human body composition of breast cancer patients based on bioelectrical impedance technology

目的分析乳腺癌患者的人体成分及其随年龄变化的情况,比较不同诊断标准下乳腺癌患者的肥胖发生率,了解体质量指数(BMI)与各人体成分指标之间的关系,调查乳腺癌患者的肌肉减少症发生率及其与肥胖的关系。方法选取女性乳腺癌患者1187例,在术前利用生物电阻抗技术分析患者的人体成分。结果乳腺癌患者各人体成分指标的年龄组间差异有统计学意义(F值为3.767~32.627,P<0.01),不同年龄组患者的肌肉减少症发生率不同(χ^2值为20.819,P<0.01);不同诊断方法的肥胖检出率不相同,应用体脂百分比(PBF)诊断的肥胖率最高,334例占28.14%的乳腺癌患者出现BMI正常或过低但PBF超标的"隐形肥胖";BMI与各人体成分指标均呈正相关(r值为0.137~0.954,P<0.01),与PBF和骨骼肌含量均呈中等程度相关(r值分别为0.761、0.534,P值均<0.01);肌肉减少症在乳腺癌患者中的发生率为98例占8.26%,BMI诊断正常仍有64例占8.78%的患者发生了肌肉减少症,PBF超标和内脏脂肪面积(VFA)超标的患者中分别有47例占6.70%和15例占5.98%出现了肌肉减少症。结论乳腺癌患者中PBF肥胖的发生比例较高,部分患者出现肌肉减少症,不利于预后,应当加强对其脂肪和肌肉含量的监测并及早干预;生物电阻抗技术能准确评估患者的人体成分,能发现传统的BMI无法诊断的"隐形肥胖"和肌肉减少症,值得在临床中进一步推广和应用。

Objective To analyze the body composition of breast cancer patients and the changes with age;to compare the incidence of obesity in breast cancer patients with different diagnostic criteria;To understand the relationship between body mass index(BMI)and body composition;to investigate the incidence of sarcopenia and its relationship with obesity in breast cancer patients.Methods The bioelectrical impedance technique was used to analyze the body composition of 1187 female breast cancer patients before surgery.Results There was a statistically significant difference between different age groups of breast cancer patients with various body composition indicators(F values were 3.767-32.627,P<0.01),and the incidence of obesity and sarcopenia was different in different age groups(χ^2 value was 20.819,P<0.01).The obesity detection rate of different diagnostic methods was different.The obesity rate diagnosed by body fat percentage(PBF)was the highest.28.14%(334/1187)of breast cancer patients were diagnosed as"invisible obesity",which refers to normal or low BMI but excessive PBF.BMI was positively correlated with all body composition indicators(r values were 0.137-0.954,P<0.01),and moderately correlated with PBF and skeletal muscle mass(r values were 0.761,0.534,P<0.01).The incidence of sarcopenia in breast cancer patients was 8.26%(98/1187).8.78%(64/1187)of the patients with normal BMI were diagnosed as Sarcopenia.Among patients with excess PBF and excess visceral fat area,6.70%(47/1187)and 5.98%(15/1187)were diagnosed with sarcopenia,respectively.Conclusion The incidence of PBF obesity in breast cancer patients is high,and some patients have sarcopenia,which is not good for prognosis.Bioelectrical impedance technology can accurately assess the body composition of patients,and can find"invisible obesity"and sarcopenia that cannot be diagnosed by BMI,which is worthy of further promotion and application in clinical practice.