场效应晶体管生物传感器用于细胞研究进展

Advances of Field-Effect transistor Biosensor in Cell research

场效应晶体管(FET)生物传感器是一种新型生物传感器。由于它具有灵敏度高、分析速度快、试剂消耗少、操作简单、免标记等特点,特别是其高度微型化和集成化引起了生命医学领域的广泛关注。本文主要介绍场效应晶体管生物传感器的结构、制备方法与传感原理,详细介绍FET生物传感器在细胞水平神经递质和电生理检测方面的一些研究成果,并对FET传感器在未来的发展方向做出展望。

Field-effect transistor(FET)biosensors have attracted wide attention in the field of life medical science due to its high sensitivity,fast analysis speed,low reagent consumption,simple operation and label free,etc.,especially its high miniaturization and integration.Here,we mainly introduce the structure,preparation method and sensing principle of FET biosensors,summarize the latest research progress of FET biosensors in detecting signaling molecules and electrophysiology at the cellular level,and predict the development direction of FET biosensors in the future.