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HDAC2,P53,P21,Ki-67在卵巢癌中的表达及临床意义 被引量:3

The Expression and Clinical Significance of HDAC2,P53, P21 and Ki-67 in Ovarian Cancer
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摘要 为研究HDAC2,P53,P21和Ki-67在卵巢癌中的表达变化,并探讨其临床价值。方法为采用免疫组化组织芯片(TMA)检测95例卵巢肿瘤患者(49例卵巢癌、13例交界性肿瘤、33例良性肿瘤),分别检测卵巢肿瘤中的HDAC2,P53,P21,Ki-67的表达,并观察与患者5年生存率的关系。结果:与良性肿瘤组织相比,卵巢癌组织中HDAC2,P53,P21和Ki-67的表达明显增加(p<0.05)。临床分期高的卵巢癌患者Ki-67表达呈上升趋势,5年生存率与淋巴结转移及复发呈正相关(p<0.05)。结论:HDAC2,P53,P21和Ki-67在卵巢癌的发生、发展中起重要作用,其中Ki-67还可作为判断患者预后的指标之一。 Objective:To study the expression changes of HDAC2,P53,P21 and Ki-67 in ovarian cancer and to explore their clinical value.Methods:95 cases of ovarian tumor were detected by immunohistochemical tissue microarray(TMA),including 49 cases of ovarian cancer,13 cases of borderline tumor and 33 cases of benign tumor.The expressions of HDAC2,P53,P21 and Ki-67 in 95 ovarian tumors were detected,and their relationship with 5-year ovarian cancer survival rate was observed.Results:compared with benign tumor tissues,HDAC2,P53,P21 and Ki-67 expressions were significantly increased in malignant tumor tissues.The 5-year survival rate of the patients with increased Ki-67 expression was positively correlated with lymph node metastasis and recurrence(p<0.05).Conclusion:the expressions of HDAC2,P53,P21 and Ki-67 are increased in ovarian cancer,all of which play an important role in the occurrence and development of ovarian cancer,and Ki-67 can be used as one of the indicators to determine the prognosis of patients.
作者 杨娟 程国梅 党雅娜 Yang Juan;Cheng Guomei;Dang Yana(Medical College cf Yellow River University of Science and Technology,Zhengzhou City,Henan Province 450063;Department of Gynecology and Obstetrici,the Third GfiCated Hospital,Zhengzhao University,Zhengzhao City,Henan Province 450052)
出处 《黄河科技学院学报》 2020年第11期6-10,共5页 Journal of Huanghe S&T College
基金 2017年河南省科技厅科技发展项目“卵巢上皮癌中HDAC2与P21相关作用的研究”(172102310528)。
关键词 卵巢癌 组织微阵列 HDAC2 P53 P21 KI-67 ovarian cancer tissue microarray HDAC2 P53 P21 Ki-67
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