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DAPT评分系统指导下小剂量氯吡格雷联合阿司匹林对ACS患者PCI术后的疗效

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摘要 目的:探讨双联抗血小板(DAPT)评分系统指导下小剂量氯吡格雷+阿司匹林在急性冠脉综合征(ACS)患者经皮冠状动脉介入(PCI)术后的应用效果。方法:选取我院ACS患者88例,均行PCI术,且术后DAPT评分≥2分,依照治疗方案不同分为研究组(n=44)、常规组(n=44)。常规组采用75mg氯吡格雷+阿司匹林治疗,研究组采用50mg氯吡格雷+阿司匹林治疗,统计比较两组治疗前、治疗6个月后血小板聚集率、血小板功能(MA)变化趋势及不良心血管事件(MACE)发生率。结果:治疗6个月后两组血小板聚集率、MA均高于治疗前,但组间比较无显著差异(P>0.05);研究组MACE发生率4.65%低于常规组18.60%(P<0.05)。结论:DAPT评分系统指导下小剂量氯吡格雷+阿司匹林应用于ACS患者PCI术后,可降低MACE风险,同时不增加出血风险,安全性高。
出处 《黑龙江医药科学》 2020年第5期177-178,共2页 Heilongjiang Medicine and Pharmacy
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  • 1陈洁霞,唐海沁,李结华.老年不稳定心绞痛患者孤立性和弥漫性斑块的临床特征[J].中国老年学杂志,2014,34(10):2650-2652. 被引量:4
  • 2高怡,钟丽萍,谢慧玲,李晓尘,郑劲平.慢性阻塞性肺疾病患者心肺运动试验安全性分析[J].中国实用内科杂志,2013,33(S1):85-85. 被引量:3
  • 3Bliden KP,Dichiara J, Tantry US, et al. Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate? [J]. J Am Coil Cardiol,2007,49(6) :657-666.
  • 4Ioannis I, Thomas S, Erminio B, et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents [ J ]. JAMA,2005,293 ( 1 7 ) :2126 -2130.
  • 5Wang F, Stouffer GA, Waxman S, et al. Late coronary stent thrombosis : early vs. late stent thrombosis in the stent era [J]. Catheter Cardiovasc Interv,2002,55 (2) : 142-147.
  • 6Guthikonda S, Lev El, Klieiman NS. Resistance to autiplatelet therapy [ J ]. Curr Cardiol Rep, 2005,7 (4) : 242 -248.
  • 7Muller L, Besta F, Sehulz C, et al. Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement [ J ]. Thromb Haemost, 2003,89 ( 5 ) : 783-787.
  • 8Serebruany VL, Steinhubl SR, Berger PB. Variability in platelet respon- siveness to clopidogrel among 544 individuals [J]. J Am Call Cardiol, 2005,45 (2) :246-251.
  • 9Bonello L, Gaubert M, Laine M, et al. Clopidogrel response variability : etiology and clinical relevance [J]. Curr Cardiovasc Risk Rep, 2015,9 (3) :1-9.
  • 10Liu Y, Liu N, Shao H, et al. Relationship of CYP2C19 * 2 and CYP2C19 * 3 gene polymorphism with elopidogrel response variability and recurrent cardiovascular events in Chinese patients undergoing percutaneous coronary intervention [J]. Pharmacology, 2013,91 ( 3-4 ) : 165-172.

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