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我国骨髓增生异常综合征的诊治现况及挑战 被引量：5

Current status and challenges on the diagnosis and treatment of myelodysplastic syndrome in China
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摘要 1982年法国、美国、英国(French-American-British,FAB)协作组根据此前提出的难治性贫血、获得性特发性铁粒幼红细胞性贫血、原始细胞增多的难治性贫血和慢性粒单核细胞白血病的共同特征外周血细胞计数一系或多系减少和骨髓一系或多系髓系造血发育异常(其表征为血细胞形态异常)提出了骨髓增生异常综合征(myelodysplastic symdromes,MDS)的概念及分型诊断标准"1。在过去的三十余年里,MDS的诊断和分型诊断标准、预后分组系统和治疗策略等方面均日臻完善。本文就我国MDS的诊治现况和存在的主要挑战作一概述。
作者 肖志坚 XIAO Zhijian
机构地区 中国医学科学院血液病医院MDS诊疗中心
出处 《内科理论与实践》 2020年第5期281-284,共4页 Journal of Internal Medicine Concepts & Practice
关键词 骨髓增生异常综合征 克隆性造血 细胞形态学
分类号 R733.3 [医药卫生—肿瘤]
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  • 1王世宏,徐泽锋,杨栋林,张莉,郝玉书,肖志坚.CAG方案治疗中高危骨髓增生异常综合征和急性髓系白血病的疗效观察[J].临床血液学杂志,2007,20(3):131-133. 被引量：20
  • 2Rigolin GM, Bigoni R, Milani R, et al. Clinical importance of interphase cytogenetics detecting occult chromosome lesions in myelodysplastic syndromes with normal karyotype. Leukemia, 2001,15:1841-1847.
  • 3Romeo M, Chauffaille Mde L, Silva MR, et al. Comparison of cytogenetics with FISH in 40 myelodysplastic syndrome patients. Leuk Res, 2002, 26:993-996.
  • 4Bernasconi P, Cavigliano PM, Boni M, et al. Is FISH a relevant prognostic tool in myelodysplastic syndromes with a normal chromosome pattern on conventional cytogenetics? a study of 57 patients. Leukemia, 2003, 17:2107-2112.
  • 5Yang W, Stotler B, Sevilla DW, et al. FISH analysis in addition to G-band karyotyping: utility in evaluation of myelodysplastic syndromes?. Leuk Res, 2010, 34:420-425.
  • 6Kettering RP, Wyatt WA, VanWier SA, et al. Primary myelodysplastic syndrome with normal cytogenetics: utility of ' FISH panel testing' and M-FISH. Leuk Res, 2002, 26:235-240.
  • 7Cherry AM, Brockman SR, Paternoster SF, et al. Comparison of interphase FISH and metaphase cytogenetics to study myelodysplastic syndrome : an Eastern Cooperative Oneology Group ( ECOG ) study. Leuk Res, 2003, 27, 1085-1090.
  • 8Beyer V, Castagne C, Mtihlematter D, et al. Systematic screening at diagnosis of - 5/del (5) ( q31 ) , - 7, or chromosome 8 aneuploidy by interphase fluorescence in situ hybridization in 110 acute myelocytic leukemia and high risk myelodysplastic syndrome patients: concordances and discrepancies with conventional cytogenetics. Cancer Genet Cytogenet, 2004, 152:29-41.
  • 9Mallo M, Arenillas L, Espinet B, et al. Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q -. Haematologica, 2008, 93 : 1001-1008.
  • 10Pitchford CW, Hettinga AC, Reichard KK. Fluorescence in situ hybridization testing for - 5/5q, - 7/7q, + 8, and del (20q) in primary myelodysplastic syndrome correlates with conventional cytogenetics in the setting of an adequate study. Am J Clin Pathol, 2010, 133:260-264.

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内科理论与实践
2020年 第5期

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