儿童费城染色体阳性和费城染色体样急性淋巴细胞白血病的研究进展

Research progress of Philadelphia chromosome-positive and Ph-like acute lymphoblastic leukemia in children

儿童费城染色体(Philadelphia chromosome, Ph)阳性急性淋巴细胞白血病(acute lymphoblastic leukemia, ALL)在儿童ALL中占2%~5%,在青少年和年轻成人中占6%,在成年人中超过25%,发病率随年龄的增长而增加[1]。研究表明,在酪氨酸激酶抑制剂(tyrosine kinase inhibitor, TKI)出现之前.