清肺化痰汤对慢性阻塞性肺疾病急性加重期患者肺功能及炎性指标的影响

Efficacy of the Qingfei Huatan decoction on pulmonary function and inflammatory index in patients with AECOPD

目的:探讨清肺化痰汤治疗慢性阻塞性肺疾病急性加重期(Acute Exacerbations of Chronic Obstructive Pulmonary Disease,AECOPD)患者的临床疗效。方法:回顾性分析2018年2月-2019年6月期间于我院接受治疗的AECOPD患者(84例)的临床资料,视其药物治疗方案的不同给予分组,分别为对照组(常规西医治疗,42例)与观察组(常规西医治疗加清肺化痰汤,42例)。两组均连续治疗2周,观察两组入选者肺功能指标及炎性指标水平。结果:治疗后,与对照组相比,观察组第一秒用力呼气容积(Forced Expiratory Volume in One Second,FEV1)、最大通气量(Maximum Ventilatory Volume,MVV)、呼气峰值流量(Peak Expiratory Flow,PEF)水平较高,C反应蛋白(C-reactive Protein,CRP)、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)水平较低,差异有统计学意义(P<0.05)。结论:清肺化痰汤治疗AECOPD患者,利于改善患者肺功能,减轻炎症反应。

Objective:To explore the clinical efficacy of the Qingfei Huatan decoction(清肺化痰汤)on AECOPD.Methods:Depending on their treatment regimens,84 cases were divided into the control groups(received conventional Western medicine treatment,42 cases)and the observation group(received the Qingfei Huatan decoction more,42 cases).Results:After treatment,compared with the control group,FEV1,MVV,PEF level in the observation group were higher,and the levels of CRP,IL-6,TNF-αwere lower,with statistically significant differences(P<0.05).Conclusion:The Qingfei Huatan decoction on AECOPD is beneficial to improve the lung function and reduce inflammation of the patients.