2Bergot E,Sitbon 0, Cottin V,et al. Current epoprostenol use inpatients with severe idiopathic, heritable or anorexigen-associatedpulmonary arterial hypertension : data from the French pulmonaryhypertension registry[j]. Int J Cardiol, 2014,172(3) :561-567.
3Simonneau G, Barst RJ, Galie N,et al. Continuous subcutaneousinfusion of treprostinil, a prostacyclin analogue, in patients withpulmonary arterial hypertension : a double-blind, randomized,placebo-controlled trial[j]. Am J Respir Crit Care Med, 2002,165(6):800-804.
4Hiremath J, Thanikachalam S, Parikh K, et al. Exerciseimprovement and plasma biomarker changes with intravenoustreprostinil therapy for pulmonary arterial hypertension : a placebo-controlled trial [j]. J Heart Lung Transplant, 2010,29(2): 137-149.
5McLaughlin VV, Benza RL, Rubin U, et al. Addition of inhaledtreprostinil to oral therapy for pulmonary arterial hypertension : arandomized controlled clinical trial [J]. J Am Coll Cardiol,2010,55(18):1915-1922.
6Tapson VF, Torres F, Kermeen F, et al. Oral treprostinil for thetreatment of pulmonary arterial hypertension in patients onbackground endothelin receptor antagonist and/orphosphodiesterase type 5 inhibitor therapy (the FREEDOM-Cstudy): a randomized controlled trial [J]. Chest,2012,142(6):1383-1390.
7Tapson VF, Jing ZC,Xu KF,et al. Oral treprostinil for thetreatment of pulmonary arterial hypertension in patients receivingbackground endothelin receptor antagonist and phosphodiesterasetype 5 inhibitor therapy (the FREEDOM-C2 study) : a randomizedcontrolled trial[ J]. Chest, 2013,144(3) :952-958.
8McLaughlin VV, Oudiz RJ, Frost A, et al. Randomized study ofadding inhaled iloprost to existing bosentan in pulmonary arterialhypertension [j].Am J Respir Crit Care Med, 2006,174(11):1257-1263.
9Rubin U, Badesch DB, Barst RJ,et al. Bosentan therapy forpulmonary arterial hypertension [J]. N Engl J Med, 2002,346(12):896-903.
10Gali b N,Rubin U,Hoeper M,et al. Treatment of patients withmildly symptomatic pulmonary arterial hypertension with bosentan(EARLY study) : a double-blind, randomised controlled trial [J].Lancet,2008,371( 9630) : 2093-2100.
