血管内皮生长因子对晶状体影响的研究进展

Recent advances on the effect of vascular endothelial growth factor to human lens

血管内皮生长因子(VEGF)是一种促血管生成因子,在许多病理性血管生成的眼部疾病中起着重要作用。目前,VEGF已成为许多疾病的治疗靶点。然而,现有研究更多关注VEGF在富含血管组织中的作用,忽略了它在非血管组织中的影响。本文中笔者将VEGF-A对晶状体胚胎血管和晶状体大小的影响,以及VEGF-A在年龄相关性白内障、糖尿病性白内障和白内障术后后囊膜混浊等疾病中的作用进行综述,旨在分析VEGF-A对晶状体的影响机制,以期为相关的临床研究提供理论依据。

Vascular endothelial growth factor(VEGF)has been the treatment target of many eye diseases because of its key role in pathological angiogenesis as a pro-angiogenic factor.More attention has been paid to its role in tissues with rich invessels,but not to those lack of vessels.As an important refractive media in the eye,the lens is short of vascular tissues.In this paper,the effect of VEGF-A on embryonic vasculature of human lens,age-related cataract,diabetic cataract and posterior capsule opacification were reviewed so as to analyze the effect of VEGF-A on human lens and its possible mechanism,as well as to provide the oretical basis for relevant clinical studies.