慢性阻塞性肺疾病急性加重期患者血清补体C5a水平及其与肺功能、IL-6.CRP水平相关性研究

The levels of serum C5a and its association with pulmonary function,IL-6 and CRP levels in patients with acute exacerbation of chronic obstructive pulmonary disease

目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清补体C5a水平及其与肺功能、IL-6及CRP水平的相关性。方法:选取39例AECOPD患者,根据治疗前动脉血二氧化碳分压(PaCO2)水平分为PaCO2升高组与PaCO2正常组。另选取11例健康体检者作为正常对照组。检测治疗前AECOPD患者血清补体C5a、白介素6(IL-6)、C反应蛋白(CRP)及PaCO2,记录肺功能指标(FEV1%、FVC%)、体质量指数(BMI)及吸烟指数。检测正常对照组血清补体C5a水平。采用Pearson法分析各指标的相关性。结果:AECOPD组患者血清补体C5a水平明显高于正常对照组(P<0.01)。PaCO2升高组补体C5a水平明显高于PaCO2正常组(P<0.01),但两组中IL-6、CRP水平无统计学差异(P>0.05)。AECOPD组补体C5a水平与FEV1%、FVC%呈负相关(均P<0.01),但与IL-6、CRP、BMI及吸烟指数无明显相关性(均P>0.05)。结论:AECOPD患者血清补体C5a水平与肺功能有明显相关性,COPD患者CO2潴留时,补体C5a水平明显增高。

Objective:To investigate the levels of serum C5 a and its association with pulmonary function,IL-6 and CRP levels in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:39 patients with AECOPD were divided into PaCO2 elevated group and PaCO2 normal group according to PaCO2 level before treatment.Another 11 healthy people were selected as normal control group.The serum levels of C5 a,IL-6,CRP and PaCO2 were measured before treatment.Pulmonary function indexes(FEV1%,FVC%),body mass index(BMI) and smoking index were recorded.The serum level of C5 a was detected in normal control group.Pearson method was used to analyze the correlation of each index.Results:The serum C5 a level in AECOPD group was significantly higher than that in normal control group(P<0.01).The level of C5 a in PaCO2 elevated group was significantly higher than that in PaCO2 normal group(P<0.01),but there was no significant difference in the levels of IL-6 and CRP between the two groups(P>0.05).The level of C5 a was negatively correlated with FEV1% and FVC% in AECOPD group(all P<0.01),but not with IL-6,CRP,BMI and smoking index(all P>0.05).Conclusion:Serum C5 a is associated with lung function of patients with AECOPD.Moreover,serum C5 a is higher when the patients have carbon dioxide retention.