胞磷胆碱联合Rood技术治疗老年脑卒中临床研究

Clinical Study of Citicoline Combined with Rood Technology in the Treatment of Elderly Patients with Stroke

目的探讨胞磷胆碱联合Rood技术治疗老年脑卒中的临床疗效及对患者日常生活能力的影响。方法选取医院2017年9月至2019年9月收治的老年脑卒中患者92例,按随机数字表法分为观察组和对照组,各46例。两组患者均予脑卒中常规治疗,并予Rood技术治疗,观察组患者加服胞磷胆碱钠片。两组均连续治疗4周。结果观察组总有效率为86.96%,明显高于对照组的69.56%(P<0.05);治疗后,观察组患者的美国国立卫生研究院卒中量表(NIHSS)评分明显低于对照组,简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分及Fugl-Meyer评分、Barthel指数评分均明显高于对照组(P<0.05)、神经元特异性烯醇化酶(NSE)、S100β蛋白、碱性髓鞘蛋白(MBP)水平均明显低于对照组(P<0.05);观察组与对照组不良反应发生率相当(17.39%比10.87%,P>0.05)。结论胞磷胆碱联合Rood技术治疗老年脑卒中,能改善神经缺损状态,降低脑损伤血清标志物水平,改善日常生活能力。

Objective To investigate the clinical efficacy of Citicoline Sodium Tablets combined with Rood technology in the treatment of elderly patients with stroke and its effect on the activities of daily living(ADL).Methods Totally 92 elderly patients with stroke admitted to our hospital from September 2017 to September 2019 were selected and randomly divided into the observation group and the control group,46 cases in each group.The patients in the two groups were given the routine treatment of stroke and Rood technology,while the patients in the observation group were treated with Citicoline Sodium Tablets.Both groups were continuously treated for 4 weeks.Results The total effective rate of the observation group was 86.96%,which was significantly higher than 69.56%of the control group(P<0.05).After treatment,the National Institute of Health Stroke Scale(NIHSS)score in the observation group was significantly lower than that in the control group,the Mini-Mental State Examination(MMSE)score,Montreal Cognitive Assessment(MOCA)score,Fugl Meyer score and Barthel index score in the observation group were significantly higher than those in the control group(P<0.05),while the levels of neuron-specific enolase(NSE),S100β protein and basic myelin basic protein(MBP)in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(17.39%vs.10.87%,P>0.05).Conclusion Citicoline combined with Rood technology in the treatment of elderly patients with stroke can improve the state of nerve defect,reduce the levels of serum markers of brain injury,and improve the patients with ADL.