甲泼尼龙琥珀酸钠联合人免疫球蛋白在腺病毒性肺炎的临床应用

Clinical Application of Methylprednisolone Sodium Succinate in Adenovirus Pneumonia

目的探讨腺病毒性肺炎患儿采取甲泼尼龙琥珀酸钠(甲强龙)联合人免疫球蛋白的治疗效果。方法选取2019年5月至2020年3月本院接收的30例腺病毒性肺炎患儿,随机分为两组,各15例,对照组采取单一的甲强龙治疗,研究组则接受甲强龙联合人免疫球蛋白治疗,统计各组临床治疗效果、住院时间、发热持续时间及不良反应发生率。结果在治疗总有效率方面,研究组是93.33%,对照组是60.00%,研究组较对照组更高,差异有统计学意义(P<0.05);在住院时间、发热持续时间方面,研究组均同对照组相比偏低,差异均有统计学意义(P<0.05);研究组与对照组不良反应发生率分别是13.33%和20.00%,两组对比,未见明显差异(P>0.05)。结论腺病毒性肺炎治疗期间,应用甲强龙联合人免疫球蛋白治疗方法,不仅可以缩短发热持续时间,同时有助于治疗效果提高,减少患儿住院时间,且安全性高,值得推广、采纳。

Objective To investigate the therapeutic effect of methylprednisolone combined with immunoglobulin in children with adenovirus pneumonia.Methods From May 2019 to March 2020,30 children with adenovirus pneumonia received by our hospital were randomly divided into two groups,15 cases each,the control group was treated with a single methylprednisolone,and the study group was treated with methylprednisolone combined with immunoglobulin.Results In the total effective rate of treatment,the study group was 93.33%,the control group was 60.00%,the study group was higher than the control group,the difference was statistically significant(P<0.05),the study group was lower than the control group in terms of hospitalization time and duration of fever,the difference was statistically significant(P<0.05),the incidence of adverse reactions between the study group and the control group was 13.33%and 20.00%,the two groups were not significantly different(P>0.05).Conclusion During the treatment of adenovirus pneumonia,the use of methylprednisolone combined with immunoglobulin can not only shorten the duration of fever,but also help to improve the treatment effect,reduce the hospitalization time of children,and have a high safety,which is worth popularizing and adopting.