替普瑞酮辅助治疗对老年Hp阳性慢性萎缩性胃炎患者血清G-17、PG及免疫功能的影响

Effect of combined Triple Therapy of Folic Acid and Teprenone on Serum G-17,PG and Immune Function in Elderly Patients with Hp-positive Chronic Atrophic Gastritis

目的探讨叶酸和替普瑞酮联合三联疗法对老年幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)患者的价值。方法选择我院2018年9月至2019年9月50例老年Hp阳性CAG患者。按数字随机法分为观察组(替普瑞酮、叶酸与三联疗法治疗)和对照组(叶酸与三联疗法治疗),每组25例。结果治疗后:观察组治疗效果优于对照组(P<0.05);观察组G-17、PGⅠ较对照组高,PGⅡ较对照组低(均P<0.05);观察组CD4+和CD4+/CD8+较对照组高,CD8+较对照组低(P<0.05);两组不良反应发生率(P>0.05)。结论替普瑞酮和叶酸联合三联疗法治疗老年Hp阳性CAG患者疗效效果确切,使胃黏膜的损伤转归,使免疫力增强而无严重不良反应。

Objective To investigate the effect of folic acid and teprenone combined triple therapy on serum gastrin-17(G-17),pepsinogen(PG)and immune function in elderly patients with Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG).Methods Selected 50 elderly Hp-positive CAG patients from September 2018 to September 2019 in our hospital.Randomly divided into observation group(teprenone,folic acid and triple therapy)and control group(folic acid and triple therapy),25 cases in each group.Results After treatment:The total effective rate of treatment in the observation group was 92.00%,significantly higher than 68.00%in the control group(P<0.05).G-17 and PGⅠin the observation group were higher than the control group,and PGⅡwas lower than the control group(both P<0.05).The CD4+and CD4+/CD8+of the observation group were higher than the control group,and the CD8+was lower than the control group(P<0.05).The incidence of adverse reactions in the two groups(P>0.05).Conclusion The combined triple therapy of teprenone and folic acid in the treatment of elderly Hp-positive CAG patients has definite curative effect,which makes the gastric mucosal injury better,and enhances immunity without serious adverse reactions.