Ozurdex治疗眼后段疾病引起的黄斑水肿被引量：3

Ozurdex in the treatment of macular edema caused by posterior ophthalmic diseases

导出

摘要黄斑水肿是眼底病患者视功能减退的主要原因之一。多种因素造成血-视网膜屏障的破坏,形成黄斑水肿,其中炎性反应在形成黄斑水肿中发挥着重要作用。为克服传统玻璃体内注射糖皮质激素的局限性,具有良好的临床效果、独特的药物缓释系统的地塞米松玻璃体内植入剂Ozurdex为黄斑水肿治疗提供新的选择,其在治疗视网膜静脉阻塞、糖尿病视网膜病变、非感染性葡萄膜炎等眼底疾病继发的黄斑水肿有良好的疗效和安全性。 Macular edema is one of the main causes of visual dysfunction in patients with fundus disease.Many factors cause the destruction of blood-retinal barrier and form macular edema,among which inflammation plays an important role in the formation of macular edema.In order to overcome the limitations of traditional intravitreous hormone injection,dexamethasone vitreous implant(Ozurdex)came into being.Its good clinical effect and unique drug delivery system provide a new choice for the treatment of macular edema.Ozurdex has good efficacy and safety in the theatment of macular edema caused by fundus diseases such as retinal vein occlusion,diabetic retinopathy and non-infective uveitis.

作者谭丛秦梅 Tan Cong;Qin Mei(Department of Ophthalmology,the First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233000,China)

机构地区蚌埠医学院第一附属医院眼科

出处《国际眼科纵览》 2020年第5期346-350,共5页 International Review of Ophthalmology

关键词 Ozurdex 黄斑水肿视网膜静脉阻塞糖尿病性黄斑水肿非感染性葡萄膜炎 Ozurdex macular edema retinal vein occlusion diabetic macular edema noninfectious uveitis

分类号 R774.5 [医药卫生—眼科]

引文网络
相关文献

参考文献3

1Fernanda Pacella,Maria Rosaria Romano,Paolo Turchetti,Giovanna Tarquini,Anna Carnovale,Antonella Mollicone,Alessandra Mastromatteo,Elena Pacella.An eighteen-month follow-up study on the effects of Intravitreal Dexamethasone Implant in diabetic macular edema refractory to anti-VEGF therapy[J].International Journal of Ophthalmology(English edition),2016,9(10):1427-1432. 被引量：5
2Leonardo Mastropasqua,Silvio Di Staso,Rossella D’Aloisio,Alessandra Mastropasqua,Luca DiAntonio,Alfonso Senatore,Marco Ciancaglini,Marta Di Nicola,Giuseppe Di Martino,DanieleTognetto,Lisa Toto.Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study[J].International Journal of Ophthalmology(English edition),2019,12(10):1589-1597. 被引量：3
3王康,王艳玲,高立新,李新民,李明铭.地塞米松玻璃体内注射对血-视网膜屏障通透性及VEGF影响[J].眼科新进展,2008,28(4):259-262. 被引量：4

二级参考文献16

1王康,刘乃慧,李新民.两种糖尿病大鼠模型血-视网膜屏障对EB通透性的比较[J].眼科新进展,2007,27(1):22-24. 被引量：9
2Massin P, Audren F, Haouchine B, Erginay A, Bergmann d-F, Benosman R, et cd. Intravitreal triamcinolone acetonide for diabetic diffuse macular edema:preliminary results of a prospective controlled trial[ J]. Ophthalmology 2004; 111:218-224.
3Sutter FK, Simpson JM, Gillies MC. Intravitreal triamcinolone for diabetic macular edema that persists after laser treatment: three months efficacy and safety results of a prospective, randomized, double-masked, placebo-controlled clinical trial[ J]. Ophthalmology 2004; 111: 2044- 2049.
4Tamttra H,Miyamoto K, Kiryu J, Miyahara S, Katsuta H, Hirose F, et al. Intravitreal injection of corticosteroid attenuates leukostasts and vascular leakage in experimental diabetic retina [ J ]. Invest Ophthalmol Vis Sci 2005 ; 46: 1440-1444.
5Xu Q, Qaum T,Adamis AP. Sensitive blood-retinal barrier breakdown quantitation using Evans blue[ J ]. Invest Ophthalmol Vis Sci.2001; 42-789-794.
6Iijima K,Yoshikawa N,Connolly DT,Nakamura H. Human mesangial cells and peripheral blood mononuclear cells produce vascular permeability factor[ J ]. Kidney Int 1993 ; 44:959-966.
7Horiuchi T, Weller PF. Expression of vascular endothelial growth factor by human eosinophils :upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5 [ J]. Am J Respir Cell Mol Biol 1997 ;17:70-77.
8Freeman MR, Schneck FX, Gagnon ML, Corless C, Soker S,Niknejad K, et al. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenests[ J]. Cancer Res 1995 ;55:4140-4145.
9Mohle R, Green D,Moore MA,Nachman RL, Rafii S. Constitutive production and thrombin- induced release of vascular endothelial growth factor by human megakaryocytes and platelets [ J]. Proc Natl Acad Sci USA 1997 ;94:663-668.
10Gaudry M, Bregerie O, Andrieu V, Benna J, Pocidalo MA, Hakim J. Intracellular pool of vascular endothelial growth factor in human neutrophils[ J]. Blood 1997 ;41:4153-4161.