生长抑素联合乌司他丁治疗急性重症胰腺炎对患者血清自然杀伤细胞与肿瘤坏死因子水平影响

Effect of Somatostatin Combined with Ulinastatin in the Treatment of Acute Severe Pancreatitis on the Levels of Serum Natural Killer Cells and Tumor Necrosis Factor

目的探讨生长抑素联合乌司他丁治疗急性重症胰腺炎的临床应用。方法研究对象选取该院2018年2月—2019年8月间收治的急性重症胰腺炎患者62例,随机分为对照组和联合用药组,每组31例。对照组给予乌司他丁,联合用药组给予生长抑素联合乌司他丁。检测两组血清自然杀伤细胞、肿瘤坏死因子、内源性生长抑素水平;统计两组总有效率;统计两组住院时间、病死率。结果联合用药组总有效率显著高于对照组(P<0.05)。治疗后,联合用药组NK细胞比例为(52.36±5.63)%,对照组NK细胞比例为(41.32±4.55)%,联合用药组NK细胞比例显著高于对照组(t=8.490,P<0.05)。联合用药组TNF水平为(9.33±2.72)ng/mL,对照组TNF水平为(17.32±4.20)ng/mL,联合用药组TNF水平显著低于对照组(t=8.890,P<0.05)。联合用药组住院时间显著少于对照组(P<0.05)。联合用药组内源性SS水平显著低于对照组(P<0.05)。联合用药组病死率显著低于对照组(P<0.05)。结论生长抑素联合乌司他丁治疗急性重症胰腺炎的临床效果显著,能够提高血清NK细胞比例,降低外周血TNF水平,从而提高治疗效果。

Objective To explore the clinical application of somatostatin combined with ulinastatin in the treatment of acute severe pancreatitis.Methods The study subjects selected 62 patients with severe acute pancreatitis admitted to the hospital from February 2018 to August 2019,and randomly divided them into a control group and a combination group,with 31 cases in each.The control group was given ulinastatin,and the combination group was given somatostatin and ulinastatin.The serum levels of natural killer cells,tumor necrosis factor,and endogenous somatostatin were detected in the two groups;the total effective rate of the two groups was counted;the length of stay and the mortality rate of the two groups were counted.Results The total effective rate of the combination group was significantly higher than that of the control group(P<0.05).After treatment,the proportion of NK cells in the combination group was(52.36±5.63)%,and the proportion of NK cells in the control group was(41.32±4.55)%.The proportion of NK cells in the combination group was significantly higher than that in the control(t=8.490,P<0.05).The TNF level in the combination group was(9.33±2.72)ng/mL,and the TNF level in the control group was(17.32±4.20)ng/mL.The TNF level in the combination group was significantly lower than that in the control group(t=8.890,P<0.05).The length of hospital stay in the combination group was significantly less than that in the control group(P<0.05).The level of endogenous SS in the combination group was significantly lower than that in the control group(P<0.05).The fatality rate of the combination group was significantly lower than that of the control group(P<0.05).Conclusion Somatostatin combined with Ulinastatin has a significant clinical effect in the treatment of acute severe pancreatitis, which can increase the proportion of serum NK cells and reduce the level of peripheral blood TNF, thereby improving the therapeutic effect.