雷珠单抗玻璃体内注射治疗视网膜静脉阻塞黄斑水肿

Intravitreal Injection of Ranibizumab in Treatment of Macular Edema Due to Retinal Vein Occlusion

目的评价视网膜静脉阻塞黄斑水肿采取雷珠单抗玻璃体内注射治疗的可行性和临床效果,为此类疾病治疗工作提供参考。方法选择该院2018年7月—2019年12月期间收治的80例视网膜静脉阻塞黄斑水肿疾病患者为研究对象,共100患眼,结合治疗方法进行80例患者随机分组治疗。研究组40例患者采取雷珠单抗玻璃体内注射治疗,对照组40例患者采取曲安奈德玻璃体内注射治疗,比较两组视网膜静脉阻塞黄斑水肿患者治疗效果、药物不良反应情况以及矫正后视力水平、中心凹厚度、眼压改善情况。结果治疗前两组患者的矫正后视力水平、中心凹厚度、眼压差异无统计学意义(P>0.05),治疗后两组上述指标均较治疗前改善,且研究组患者改善幅度更大(P<0.05);研究组与对照组患者治疗后总有效率(95.0%vs 75.0%)对比,差异有统计学意义(χ2=6.274,P<0.05),不良反应发生率(7.5%vs 25.0%)对比,差异有统计学意义(χ2=4.501,P<0.05)。结论对比曲安奈德玻璃体内注射治疗,雷珠单抗玻璃体内注射治疗视网膜静脉阻塞黄斑水肿兼具安全性、有效性价值,助于患者视力、中心凹厚度、眼压改善,是优选治疗方案。

Objective To evaluate the feasibility and clinical effect of intravitreal injection of ranibizumab for macular edema due to retinal vein occlusion,so as to provide reference for the treatment of such diseases.Methods Selected 80 patients with retinal vein occlusion and macular edema who were admitted to the hospital from July 2018 to December 2019 as the research subjects.A total of 100 eyes were selected for treatment.80 patients were randomly divided into groups based on treatment methods.40 patients in the study group received intravitreal injection of ranibizumab,and 40 patients in the control group received intravitreal injection of triamcinolone acetonide.The two groups of patients with retinal vein occlusion macular edema were compared with treatment effects,adverse drug reactions,and corrected visual acuity,Foveal thickness,improvement of intraocular pressure.Results Before treatment,there were no statistically significant differences in the corrected visual acuity,foveal thickness,and intraocular pressure between the two groups of patients(P>0.05).After treatment,the above indicators in the two groups were improved compared to before treatment,and the patients in the study group improved more(P<0.05);The total effective rate(95.0%vs 75.0%)between the study group and the control group after treatment is statistically significant(χ2=6.274,P<0.05),and the incidence of adverse reactions(7.5%vs 25.0%),the difference was statistically significant(χ2=4.501,P<0.05).Conclusion Compared with intravitreal injection of triamcinolone acetonide,intravitreal injection of ranibizumab in the treatment of retinal vein occlusion macular edema is both safe and effective, and it can help patients improve vision, foveal thickness, and intraocular pressure. It is the preferred treatment plan.