NF-κB介导的炎症通路与消化道肿瘤相关研究进展

Research Progress of Nf-κB-mediated Inflammation Pathway and Digestive Tract Tumors

生活水平的提高不仅给人民带来了满足感,同时也带来了健康的隐患。肿瘤就是恶性疾病的代表,而消化道肿瘤又是恶性肿瘤中常见的肿瘤,其主要分布在食管、胃、肠、肝脏等消化器官。中国恶性肿瘤发病率排行:胃癌、结直肠癌、肝癌居于2、3、4位;死亡率排行:肝癌、胃癌、食管癌、结直肠癌分别居于2、3、4、5位,情况不容忽视。为了更好地提高消化道肿瘤患者的生存率,出现了一系列肿瘤发生发展的理论机制,其中"炎症--癌症"理论就是经典理论之一。NF-κB因子是近年来研究较热的炎症因子之一,该因子介导的通路参与了许多肿瘤形成发展过程。下面就以消化道肿瘤为例,探讨其与NF-κB关系,为肿瘤靶向治疗提供理论依据。

Improvement of living standards brings satisfaction to the people,and health risks at the same tine.Tumors are representative of malignant diseases,and digestive tract tumors are common in malignant ones,which mainly distribute in digestive organs including esophagus,stomach,intestine,and liver.Malignant tumor incidence in China inlcude:stomach cancer,colorectal cancer,liver cancer ranks 2,3,and 4;in terms of mortality:liver cancer,stomach cancer,esophageal cancer,colorectal cancer ranks 2,3,4,and 5 respectively,which cannot be ignored.To improve survival rate of patients with gastrointestinal tumors,there are a series of theoretical mechanisms for tumor incidence and development,and"inflammation-cancer"theory is one of classic theories.NF-κB factor is one of the hottest inflammatory factors in recent years,whose pathway is involved in many tumor formation and development processes.With example of gastrointestinal tumors,the article discuss its relationship with NF-κB and provide theoretical basis for tumor targeted therapy.