摘要
CpG ODN是含一个或多个非甲基化CpG基序的寡聚脱氧核苷酸,根据其结构及生物学活性的不同,分为A、B、C、P四种类型,目前在家禽疾病防控方面的研究主要以B型CpG ODN为主,CpG ODN通过与鸡TLR-21受体结合发挥其免疫刺激活性,可用于防控鸡常见细菌性感染、病毒性感染以及球虫感染等。文章从CpG ODN的分类、作用机制、家禽疾病防控等方面进行阐述,为CpG ODN在家禽生产中的应用提供参考。
CpG ODN is an oligodeoxynucleotides containing one or more unmethylated CpG motifs. According to the different structure and biological activity, there are four types, which are A, B, C and P. At present, the study for poultry diseases control is mainly based on B-type CpG ODN. CpG ODN exerts its immunostimulatory activity by combining with chicken TLR-21 receptors and can be used for bacterial infection, viral infection and coccidia infection.This paper mainly discussed the classification, mechanism, control of poultry diseases, and provided a reference for application of CpG ODN in poultry production.
作者
苏胖
武力
李美娣
刘汉清
王甜
SU Pang;WU Li;LI Meidi;LIU Hanqing;WANG Tian(College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong 510642;Guangdong Huanong Hi-Tech BiologicalPharmaceutical Co.,Ltd.,Guangzhou,Guangdong 510642;Meizhou Polytechnic,Meizhou,Guangdong 514011)
出处
《中国家禽》
北大核心
2020年第10期94-99,共6页
China Poultry
