损伤控制骨科治疗策略对严重多发伤骨折患者损伤程度及血清IL-6、TNF-a,CRP水平的影响

Effect of damage control orthopedic treatment strategy on injury degree and serum levels of IL-6,TNF-a and CRP in patients with severe multiple trauma fractures

目的探讨损伤控制骨科治疗策略对严重多发伤骨折患者损伤程度及血清IL-6、TNF-α、CRP水平的影响。方法选取武安市第一人民医院2018年11月至2019年11月收治的严重多发伤骨折患者120例,按照随机数字表法将其分为试验组和对照组,各60例。对照组患者采用常规方法治疗,试验组患者采用损伤控制骨科治疗策略治疗,两组患者均进行30 d的治疗。观察并对比两组患者治疗后的总有效率,治疗前后的损伤程度及血清IL-6、TNF-α、CRP水平变化。结果治疗后试验组患者的临床总有效率为96.67%,高于对照组的85.00%;与治疗前相比,治疗后两组患者ISS评分、PPI评分及血清IL-6、TNF-α、CRP水平均降低,且试验组低于对照组(均P<0.05)。结论损伤控制骨科治疗策略可提高严重多发伤骨折患者的临床疗效,改善其损伤程度,同时可降低患者血清IL-6、TNF-α、CRP水平,进而抑制机体炎症反应。

Objective To investigate the effect of damage control orthopedic treatment strategy on the degree of injury and serum levels of IL-6,TNF-a,and CRP in patients with severe multiple trauma fractures.Methods 120 patients with severe multiple trauma fractures in Wuan First People's Hospital were selected during November 2018 to November 2019,according to the random number table method,they were divided into the experimental group and the control group,60 cases in each group.The patients in the control group were treated with conventional methods,and the patients in the experimental group were treated with damage control orthopedic treatment strategy.The patients in the both groups were treated for 30 days.The total effective rate,the degree of injury before and after treatment and the changes of serum IL-6,TNF-a and CRP levels were observed and compared between the two groups.Results The total clinical effictive rate of treatment in the experimental group was 96.67%,which was higher than 85.00%in the control group after treatment;Compared with that before treatment,ISS score,PPI score,serum IL-6,TNF-a and CRP levels of the two groups decreased after treatment,and the experimental group lower than the control group(all P<0.05).Conclusion Damage control orthopedic treatment strategy can improve the clinical efficacy and injury degree of patients with severe multiple trauma fractures,at the same time,it can reduce the levels of serum IL-6,TNF-a,and CRP in patients,thereby inhibiting the body's inflammatory response.