钙剂联合小剂量阿司匹林对子痫前期高危孕妇的预防作用研究

Study on the preventive effect of calcium combined with low-dose aspirin on pregnant women with high-risk preeclampsia

目的探究钙剂联合小剂量阿司匹林对子痫前期高危孕妇的预防作用。方法前瞻性选取2016年9月至2018年9月在襄阳市中心医院定期产检的80例子痫前期高危孕妇作为研究对象,根据随机数字表法将其分为对照组和观察组,每组各40例。对照组孕妇给予常规干预,观察组孕妇给予钙剂联合小剂量阿司匹林;观察并比较两组孕妇子痫前期发生率、母婴结局及干预前后各生化指标。结果观察组孕妇子痫前期发生率显著低于对照组(P<0.05)。干预后,观察组孕妇24 h尿蛋白、血管性假血友病因子均显著低于对照组(均P<0.05),血管内皮生长因子、活化部分凝血活酶时间均显著高于对照组(均P<0.05)。观察组早产儿占比显著低于对照组(P<0.05),分娩孕周、新生儿体重均显著大于对照组(均P<0.05)。结论小剂量阿司匹林联合钙剂可降低子痫前期发生率,改善母婴不良结局。

Objective To investigate the preventive effect of calcium combined with low-dose aspirin on pregnant women with high-risk preeclampsia.Method Prospectively selected 80 cases of high-risk preeclampsia pregnant women underwent regular obstetrics in Xiangyang Central Hospital from September 2016 to September 2018 as the research objects,and divided them into control group and observation group according to the random number table method,each with 40 cases.Pregnant women in control group were given routine intervention,and pregnant women in observation group were given calcium combined with lowdose aspirin.The incidence of preeclampsia,maternal and infant outcomes and biochemical indicators before and after intervention between the two groups were observed and compared.Result The incidence of preeclampsia in observation group was significantly lower than that in control group(P<0.05).After the intervention,the 24-hour urine protein and von Willebrand factor of observation group were significantly lower than those of control group(all P<0.05),and the vascular endothelial growth factor and activated partial thromboplastin time were significantly higher than those of control group(all P<0.05).The proportion of premature babies in observation group was significantly lower than that in control group(P<0.05),and the gestational age and weight of the newborn were significantly larger than those in control group(all P<0.05).Conclusion Low-dose aspirin combined with calcium can reduce the incidence of preeclampsia and improve adverse maternal and infant outcomes.