EMS合并EP性不孕患者的VCAM-1、Bcl-2表达

Expression of VCAM-1 and Bcl-2 in infertility patients with endometriosis and endometrial polyp

目的研究血管细胞黏附分子-1(VCAM-1)及B细胞淋巴瘤-2(Bcl-2)蛋白在子宫内膜异位症(EMS)合并子宫内膜息肉(EP)性不孕患者中的表达及相关性。方法将该院2018年1月至2019年1月收治的56例EMS合并EP性不孕患者纳为研究A组,54例EP性不孕患者纳为研究B组,比较两组息肉组织中VCAM-1及Bcl-2蛋白表达量,并根据息肉大小,将研究A组息肉分为大息肉与小息肉,比较不同大小息肉组织中VCAM-1及Bcl-2蛋白表达量,采集研究A组患者异位内膜组织,比较其异位内膜组织与息肉组织中VCAM-1及Bcl-2蛋白表达量,分析EMS合并EP性不孕患者VCAM-1与Bcl-2表达量的相关性。结果研究A组EP组织中VCAM-1及Bcl-2蛋白表达量均明显高于研究B组,差异有统计学意义(P<0.05);研究A组大息肉组织中VCAM-1及Bcl-2蛋白表达量明显高于小息肉组织,差异有统计学意义(P<0.05);研究A组异位内膜组织中VCAM-1及Bcl-2蛋白表达量明显高于息肉组织,差异有统计学意义(P<0.05);EMS合并EP性不孕患者息肉组织中VCAM-1及Bcl-2蛋白表达量无相关性(r=0.078,P=0.654)。结论EMS合并EP性不孕患者EP组织中VCAM-1及Bal-2蛋白阳性表达量明显高于单纯EP性不孕患者,在EMS合并EP性不孕患者异位内膜组织中VCAM-1及Bcl-2蛋白表达量高于息肉组织,推测异位内膜组织可能会导致息肉组织增生,但其中的具体机制尚不明确。

Objective To investigate the expression and correlation of vascular cell adhesion molecule-1(VCAM-1)and B-cell lymphoma-2(Bcl-2)in infertility patients with endometriosis(EMS)and endometrial polyp(EP).Methods A total of 56 patients with EMS and EP infertility(study group A)and 54 patients with EP infertility(study group B)in Wuhan Ren′ai Hospital from January 2018 to January 2019 were enrolled.Study group A was further divided into two subgroups according to the size of the polyps,including large polyp group and small polyp group,the expression levels of VCAM-1 and Bcl-2 in polyp tissues were compared between different groups.The ectopic endometrial tissues of study group A were collected,and the expression levels of VCAM-1 and Bcl-2 protein in the ectopic endometrial tissues and polyp tissues were compared.The correlation between VCAM-1 and Bcl-2 levels in patients with EMS and EP infertility was analyzed.Results The expression levels of VCAM-1 and Bcl-2 protein in EP tissues in study group A were significantly higher than those in study group B(P<0.05).The expression levels of VCAM-1 and Bcl-2 protein in large polyp group were significantly higher than those in small polyp group(P<0.05).The expression levels of VCAM-1 and Bcl-2 protein in ectopic endometrial tissue were significantly higher than those in polyp tissue of study group A(P<0.05).Correlation analysis showed that there was no significant correlation between VCAM-1 and Bcl-2 protein expressions in polyp tissues of patients with EMS and EP(r=0.078,P=0.654).Conclusion The expression levels of VCAM-1 and Bcl-2 protein in EP tissues of EMS combined EP infertility patients are significantly higher than those of EP infertility patients,and the expression levels of VCAM-1 and Bcl-2 protein in ectopic endometrial tissues of EMS combined EP infertility patients are higher than those in polyp tissues,suggesting that ectopic endometrial tissues might lead to polyp tissue hyperplasia,but the specific mechanism is still unclear.