摘要
微小核糖核酸(miRNA)是一组高度保守的非编码核苷酸序列,具有调控转录后基因表达的功能。miRNA通过靶向不同基因影响细胞生理和疾病发展。miRNA具有调控细胞增殖、凋亡等生物学特性,参与组织炎症损伤等病理过程,其中miR-486-5p作为近年新发现的miRNA,与肿瘤等疾病发生、发展密切相关,有望辅助疾病早期诊断、靶向治疗及预后评估。
microRNAs(miRNAs)are a group of highly conserved non-coding nucleotide sequences.Their function is to regulate post-transcriptional gene expression.miRNAs affects cell physiology and disease development by targeting different genes.miRNA regulates biological characteristics such as cell proliferation and apoptosis,and participates in pathological processes such as inflammatory injury.miR-486-5p is a newly discovered miRNA in recent years,it closely relates to the occurrence and development of diseases.miR-486-5p is expected to help in early diagnosis,targeted therapy and prognosis assessment.
作者
王倩倩(综述)
任传利(审校)
WANG Qianqian;REN Chuanli(Graduate School,Dalian Medical University,Dalian,Liaoning 116044,China;Department of Clinical Laboratory,Northern Jiangsu People′s Hospital of Jiangsu Province/Northern Jiangsu People′s Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu 225001,China)
出处
《国际检验医学杂志》
CAS
2020年第22期2801-2804,2816,共5页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目(81573220)。
