益气温阳利水方对老年阳气亏虚证慢性充血性心力衰竭血清炎症因子水平影响研究

Effect of Yiqi Wenyang Lishui Recipe on Serum inflammatory Factors in Elderly Patients with Chronic Congestive Heart Failure Due to Deficiency of Yang Qi

目的研究益气温阳利水方对老年阳气亏虚证慢性充血性心力衰竭患者血清炎症因子水平影响。方法选取医院(2016年4月—2019年1月)收治的老年慢性充血性心力衰竭患者114例,根据治疗方法不同分为两组。对照组给予西医基础治疗,观察组在西医基础治疗基础上给予益气温阳利水方治疗,分析两组患者治疗后的临床疗效。结果两组治疗前中医主证分级量化积分组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后胸闷,心悸,气短,乏力,面肢浮肿积分低于对照组(P<0.05)。两组治疗前血清炎症因子、核因子κB(NF-κB)、N末端B型脑钠肽前体(NT-proBNP)、内皮素(ET)水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后肿瘤坏死因子-α(TNF-α)、超敏-C反应蛋白(hs-CRP)、白细胞介素-17(IL-17)、NF-κB、NT-proBNP、ET水平低于对照组(P<0.05)。两组治疗前6 min步行距离组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后6 min步行距离长于对照组(P<0.05)。结论益气温阳利水方治疗老年阳气亏虚证慢性充血性可改善患者临床症状,减轻炎症反应,提高运动耐量。

Objective To study the effect of Yiqi Wenyang Lishui Recipe on serum inflammatory factors in elderly patients with chronic congestive heart failure(CHF)due to deficiency of Yang Qi.Methods A total of 114 elderly patients with CHF treated in our hospital from April 2016 to January 2019 were divided into two groups according to different treatment methods.The control group was given the basic treatment of western medicine and the observation group was treated with Yiqi Wenyang Lishui Recipe on the basis of the routine western medicine.The clinical curative effect of the two groups after treatment was analyzed.Results There was no significant difference between the two groups before treatment(P>0.05).After treatment,the scores of chest tightness,palpitation,shortness of breath,fatigue and facial limb edema in the observation group were lower than those in the control group(P<0.05).Before treatment,the serum levels of inflammatory factor and nuclear factor-κB(NF-κB),and N terminal B-type natriuretic peptide precursor(NT-proBNP)in the two groups were lower than those in the control group(P<0.05).There was no significant difference in endothelin(ET)level between groups(P>0.05).Tumor necrosis factor-α(TNF-α),hypersensitivity-C-reactive protein(hs-CRP)and leukocyte were measured in the observation group after treatment.The levels of IL-17,NF-κB,NT-proBNP and ET in the two groups were lower than those in the control group(P<0.05).There was no significant difference in the 6 min walking distance between the two groups before treatment(P>0.05).The 6 min walking distance in the observation group was longer than that in the control group(P<0.05).Conclusion Yiqi Wenyang Lishui Recipe can improve the clinical symptoms,reduce inflammatory reaction and increase exercise tolerance in elderly patients with CHF of deficiency of Yang Qi.