热毒宁注射液联合阿奇霉素治疗儿童支原体肺炎的临床效果观察

Clinical Observation of Reduning Injection combined with Azithromycin in Treatment of Mycoplasma Pneumonia in Children

目的探讨热毒宁注射液与阿奇霉素联合用药在儿童支原体肺炎中的治疗效果。方法选取医院收治的72例支原体肺炎患儿为研究对象,按随机数字表分为对照组与观察组各36例。对照组给予阿奇霉素;观察组在此基础上联合热毒宁注射液,两组均治疗2周。记录两组临床症状消失时间,血清炎性因子水平,统计2组临床疗效及治疗期间的不良反应。结果治疗后观察组肺罗音消失时间、体温恢复时间、咳嗽消失时间显著短于对照组(P <0.05);2组血清TNF-α、IL-6、IL-8、hs-CRP水平均显著降低,且观察组较对照组显著降低(P <0.05);2组患儿总不良反应发生率间无显著差异(P> 0.05)。结论热毒宁注射液联合阿奇霉素可有效抑制支原体肺炎患儿的炎性反应,缓解其临床症状,且安全性较高。

Objective To explore the therapeutic effect of reduning injection combined with azithromycin in the treatment of mycoplasma pneumonia in children.Methods 72 cases children with mycoplasma pneumonia were selected as research objects in our hospital,and they were divided into the control group and the observation group according to random number table method,with 36 cases in each group.The control group was given azithromycin and the observation group combined with reduning injection on this basis.The two groups were treated continuously for 2 weeks.The clinical symptom disappearance time was recorded in the two groups.The serum inflammatory factor levels were detected,and clinical efficacy and adverse reactions during treatment were counted in the two groups.Results The disappearance time of rale,temperature recovery time and cough disappearance time of the observation group were significantly shorter than those of the control group after treatment( P <0.05).The serum TNF-α,IL-6,IL-8 and hs-CRP levels were significantly reduced in the two groups,and were lower than those of the control group( P < 0.05).There was no significant difference in the incidence of total adverse reactions between the two groups( P > 0.05).Conclusion reduning injection combined with azithromycin can effectively inhibit the inflammatory response of children with mycoplasma pneumonia and relieve its clinical symptoms.