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血清巨噬细胞移动抑制因子、胶质纤维酸性蛋白水平与蛛网膜下腔出血患者显微夹闭术预后的相关性 被引量:1

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摘要 目的探讨血清巨噬细胞移动抑制因子(MIF)、胶质纤维酸性蛋白(GFAP)水平与蛛网膜下腔出血(SAH)患者显微夹闭术预后的相关性。方法选取舞钢市人民医院2018年9月至2020年9月收治的70例SAH患者,所有入选者均接受显微夹闭术治疗与血清MIF、GFAP水平检测。采用格拉斯哥昏迷评分(GCS)评估疾病预后,采用logistic回归分析血清MIF、GFAP水平与SAH患者显微夹闭术预后的相关性,并绘制血清MIF、GFAP水平预测接受显微夹闭术治疗SAH患者预后的受试者工作曲线(ROC),计算曲线下面积(AUC)。结果预后不良组患者血清MIF、GFAP水平均高于预后良好组患者,差异有统计学意义(P<0.05)。logistic回归分析结果显示,血清MIF、GFAP水平为接受显微夹闭术治疗SAH患者预后的影响因素(OR>1,P<0.05)。ROC曲线结果显示,血清MIF、GFAP水平预测接受显微夹闭术治疗SAH患者预后的AUC分别为0.949、0.909。结论血清MIF、GFAP水平与SAH患者显微夹闭术预后存在密切联系,且其水平升高可提示预后较差,临床可据此积极采取措施改善预后。
出处 《河南医学研究》 CAS 2020年第31期5812-5814,共3页 Henan Medical Research
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