周德敏团队在可调控、通用型CAR-T干预自身免疫疾病和肿瘤的研究方面取得进展

The group of Demin Zhou has made progress in the research on the regulation and universal chimeric antigen receptor T(CAR-T) autoimmune diseases and tumors

近日,北京大学药学院天然药物及仿生药物国家重点实验室、分子与细胞药理学系周德敏课题组分别在学术期刊《Annals of the Rheumatic Diseases》、《Cell Chemical Biology》发表了题为"In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells"(多肽链介导通用型CAR-T对自身免疫性疾病患者体外B细胞的杀伤),"Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator"(光可断裂连接臂介导通用型CAR-T对肿瘤的杀伤)的研究工作。