脓毒症的血液净化治疗新进展

New progress of blood purification therapy for sepsis

脓毒症是由宿主对感染反应失调引起的危及生命的器官功能障碍,是重症患者死亡的重要原因。当前脓毒症的治疗除了使用抗生素、改善器官功能障碍和必要时的手术治疗外,各种体外血液净化疗法也可作为调节炎症反应的辅助治疗手段。脓毒症会诱发免疫系统的调节失衡,进而导致器官功能障碍;血液净化作为脓毒症的辅助治疗方法,目的是通过清除细胞因子和内毒素,控制免疫系统相关的调节失衡。本文对脓毒症的血液净化治疗新进展作了综述。

Sepsis is a life-threatening organ dysfunction caused by the dysregulation of the host′s response to infection,and is an important cause of death in critically ill patients.In addition to the use of antibiotics,improvement of organ dysfunction,and necessary surgical treatment,various treatments of extracorporeal blood purification can also be used as an auxiliary treatment method for regulating inflammation in the current treatment of sepsis.Sepsis can induce an imbalance in the regulation of the immune system,which in turn leads to organ dysfunction.Blood purification,as an adjunct treatment of sepsis,aims to control the immune system-related imbalance of regulation via removing cytokines and endotoxins.This article reviewed the new progress of blood purification treatment for sepsis.