中药辨证内服联合穴位贴敷治疗特发性矮小症临床研究

Clinical Study on Oral Administration of Chinese Medicine Combined with Point Application Based on Syndrome Differentiation for Idiopathic Dwarfism

目的:观察中药辨证内服联合穴位贴敷治疗特发性矮小症患儿的临床疗效。方法:将70例特发性矮小症患儿按随机数字表法分为对照组和中医组,每组35例;2组患儿均给予运动训练和睡眠指导,对照组给予五维赖氨酸颗粒治疗;中医组进行辨证分型论治,包括中药内服和穴位贴敷;3个月为1个疗程,共治疗2个疗程,观察比较2组患儿治疗前后身高、体质量、骨龄变化,评价其总体临床疗效及安全性。结果:总有效率中医组为85.71%,对照组为62.86%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患儿身高、体质量及骨龄均较治疗前有明显增长(P<0.05);且中医组患儿身高、体质量明显高于对照组(P<0.05)。治疗过程中对照组未见不良反应,观察组出现贴敷部位皮肤红肿2例;2组不良反应率比较,差异无统计学意义(P>0.05)。结论:采用中药内服联合穴位贴敷辨证治疗特发性矮小症,能够明显促进患儿身高和体质量增长,且治疗用药相对安全。

Objective:To observe the clinical effect of oral administration of Chinese medicine combined with point application based on syndrome differentiation for children with idiopathic dwarfism.Methods:A total of 70 cases of children with idiopathic dwarfism were divided into the control group and the Chinese medicine group according to the random number table method,35 cases in each group.Both groups were given exercise training and sleep instruction;the control group was additionally given five vitamins and lysine granules;the Chinese medicine group was additionally given syndrome differentiation typing and treatment,namely,oral administration of Chinese medicine and point application.Both groups were treated for six months,three months being a course.The changes in body height,body mass,and bone age before and after treatment were observed and compared between the two groups.The total clinical effect and safety were evaluated in the two groups.Results:The total effective rate was 85.71%in the Chinese medicine group and 62.86%in the control group,the difference being significant(P<0.05).After treatment,the body heights,body masses,and bone ages of children in the two groups were significantly increased when compared with those before treatment(P<0.05).In the Chinese medicine group,the body height and body mass of children were significantly higher than those in the control group(P<0.05).No adverse reactions occurred in the control group during treatment,and two cases of redness and swelling of skin occurred in the location of point application in the observation group.When compared the incidence of adverse reactions between the two groups,there was no significance in the difference(P>0.05).Conclusion:In treatment of idiopathic dwarfism,theoral administration of Chinese medicine combined with point application based on syndrome differentiation can significantly improve body height and body mass of children with relatively safe medication for treatment.