小儿肺咳颗粒联合阿奇霉素治疗小儿肺炎支原体肺炎临床研究及对炎性因子表达的影响

Clinical Study on Xiao’er Feike Granules Combined with Azithromycin for Mycoplasmal Pneumonia in Children and Its Effect on Expression of Inflammatory Factors

目的:探究对于小儿肺炎支原体肺炎采用小儿肺咳颗粒与阿奇霉素联合治疗方案,对患儿临床疗效及相关炎性因子表达的影响。方法:将小儿肺炎支原体肺炎患者150例按照随机数字表法分为2组各75例,对照组给予阿奇霉素治疗,观察组在对照组基础上配合小儿肺咳颗粒治疗,比较2组患者的临床疗效、炎症细胞因子表达及并发症。结果:对照组总有效率为88.0%,观察组为97.3%,2组比较,差异有统计学意义(P<0.05)。经治疗,2组炎症因子水平较前改善(P<0.05)。治疗后2组间比较,差异有统计学意义(P<0.05)。治疗期间,对照组不良反应发生率为14.7%,观察组为4.0%,2组比较,差异有统计学意义(P<0.05)。结论:在阿奇霉素治疗的基础上联合小儿肺咳颗粒能够改善小儿肺炎支原体肺炎临床症状,提高临床疗效,降低相关炎症因子的表达及并发症的发生风险。

Objective:To discuss the clinical effect of Xiao’er Feike granules combined with azithromycin for mycoplasmal pneumonia in children and its effect on expression of related inflammatory factors.Methods:A total of 150 cases of children with mycoplasmal pneumonia were divided into the control group and the observation group according to the random number table method,75 cases in each group.The control group was given azithromycin,and the observation group was additionally treated with Xiao’er Feike granules based on the treatment of the control group.The difference of clinical effect,expression of inflammatory factors and complications between the two groups were compared.Results:The total effective rate was88.0%in the control group and 97.3%in the observation group,the difference being significant(P<0.05).After treatment,the levels of inflammatory factors in the two groups were improved when compared with those before treatment(P<0.05),and there was significance in the difference between the two groups(P<0.05).During treatment,the incidence of adverse reactions was 14.7%in the control group and 4.0%in the observation group,the difference being significant(P<0.05).Conclusion:Based on the treatment of azithromycin,the additional application of Xiao’er Feike granules can significantly improve clinical effect of mycoplasmal pneumonia in children,and reduce the expression of related inflammatory factors as well as the incidence of complications.