摘要
人体内肠道菌群数量庞大,功能复杂,在促进食物消化吸收、免疫调节、物质代谢、维护机体健康和疾病的防控方面发挥重要作用。儿童属特殊群体,由于其肠道发育不完善,肠道菌群容易受分娩方式、喂养方式、抗生素应用等多种外部因素的影响。肠道菌群的紊乱会阻碍肠道功能的发挥,引起儿童营养不良甚至疾病的发生。此综述主要关注近年临床上儿童难治性消化系统疾病肠道菌群的变化,总结肠道菌群参与调节肠道免疫反应的机制,以及肠道菌群之间制约消长的关系,以寻找调节免疫反应的有益菌株。
Intestinal microflora in human body has a large number and complex functions.It plays an important role in promoting food digestion and absorption,immune regulation,material metabolism,maintaining body health and disease prevention.Due to the immature intestine in children,the diversity and abundance of intestinal flora are easily affected by many external factors,such as delivery mode,feeding mode and antibiotic application.The disorder of intestinal flora will hinder the development of intestinal function and cause malnutrition and even diseases in children.This review focuses on the changes of the intestinal flora in children with refractory digestive diseases in recent years.It summarized the mechanism of intestinal flora involved in the regulation of intestinal immune response,and the relationship between intestinal flora restricting growth and decline,so as to find beneficial strains to regulate immune response.
作者
江木秀
沐晓芹
Jiang Muxiu;Mu Xiaoqin(Department of neonatology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Genomics Research Center,College of Pharmacy,HMU-UCCSM Center for Infection and Genomics,Translational Medicine Research and Cooperation Center of Northern China,Heilongjiang Academy of Medical Sciences,Harbin 150086,China)
出处
《国际免疫学杂志》
CAS
2020年第5期530-536,共7页
International Journal of Immunology
基金
国家自然科学青年基金(81903631)黑龙江省普通本科高等学校青年创新基金(UNPYSCT-2018065)。
关键词
消化道疾病
儿童
肠道菌群
免疫机制
粪菌移植
Gastrointestinal disorders
Children
Intestinal microbiota
Immunoregulatory mechanism
Faecal microbiota transplantation