新型冠状病毒肺炎康复者恢复期血浆抗体效价观察

Observation on IgG antibody titer in plasma donated by recovered COVID-19 patients,Wuhan

目的回顾性分析新冠肺炎康复者恢复期血浆IgG抗体效价,尽量减少因抗体水平太低,导致采集到的恢复期血浆不合格而浪费。方法使用化学发光技术重新测定23位重复捐献血浆者的49例血浆标本中IgG抗体效价。结果观察期内11位捐献血浆者的抗体效价不变,10位捐献血浆者抗体效价下降,2位捐献血浆者抗体效价上升。10例血浆抗体效价下降案例发生在14-44 d的检测间隔期中。结论康复者在出院后1个月内所捐献的血浆IgG抗体水平普遍较高,这为有效筛选供体,收集高效价水平的恢复期血浆提供了指导依据,同时也为观察抗体特征提供了有力的经验支持。

Objective To retrospectively analyze the IgG antibody titer of recovered COVID-19 patients, so as to avoid the collection of unqualified CP due to insufficient antibody titers.Methods The IgG antibody titer of 49 blood specimens obtained from 23 repeat convalescent plasma(CP) donors were re-tested using chemiluminescence assay. Results During the observation period, persisting neutralizing activity of IgG antibody was maintained in 11 CP donors, declined activity in 10 donors, and enhanced activity in 2. The activity of IgG antibody declined during 14-44 d donation interval. Conclusion The IgG antibody titers in CP donated by recovered COVID-19 patients within one month after discharge was generally high, which provides guiding data for collecting CP with sufficient antibody titer, and also provides references for observing the antibody responses.