同型半胱氨酸水平与慢性心力衰竭的相关性研究

Study on the relationship between homocysteine and chronic heart failure

目的:探讨血清同型半胱氨酸(Hcy)水平与慢性心力衰竭的关系。方法:2015年5月-2018年5月收治慢性心力衰竭患者110例,作为观察组;选同时期非心衰患者50例,作对照组。比较两组N端前脑钠肽(NTpro-BNP)、Hcy水平及左心射血分数。结果:观察组NTpro-BNP及Hcy水平均明显高于对照组,差异有统计学意义(P<0.05);心功能Ⅱ级与Ⅳ级左心射血分数比较,差异有统计学意义(P<0.05);观察组NTpro-BNP与血浆Hcy水平明显呈正相关(P<0.05)。结论:血浆Hcy水平与心力衰竭存在相关性,可能参与心力衰竭的病理生理过程,成为心力衰竭的治疗靶点及诊断标志物。

Objective:To explore the relationship between serum homocysteine(Hcy)level and chronic heart failure.Methods:From May 2015 to May 2018,110 patients with chronic heart failure were selected as the observation group.50 patients with non-heart failure at the same period were selected as the control group.The NTpro-BNP,Hcy levels and left heart ejection fraction were compared between the two groups.Results:The levels of NTpro-BNP and Hcy in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The difference of left ventricular ejection fraction between gradeⅡand gradeⅣof cardiac function was statistically significant(P<0.05).NTpro-BNP in the observation group was positively correlated with plasma Hcy levels(P<0.05).Conclusion:There is a correlation between plasma Hcy level and heart failure,which may participate in the pathophysiological process of heart failure,and become a therapeutic target and diagnostic marker for heart failure.