视网膜α-crystallins在增生性视网膜疾病中的研究进展

Research progress of retinalα-crystallins in proliferative retinal diseases

α-crystallins是小分子热休克蛋白家族(small-molecule heat shock protein,sHSP)的重要成员,包括αA-crystallin和αB-crystallin,在各类组织细胞中具有细胞保护和分子伴侣功能。近年来,多项研究发现,视网膜组织α-crystallins可利用自身特性通过各种途径参与增生性视网膜病的血管新生、上皮/内皮细胞间质化等过程。本文主要介绍α-crystallins,尤其是αB-crystallin调节增生性视网膜疾病发展的分子机制,探讨其潜在的临床应用价值。

α-crystallins are an important member of the small-molecule heat shock protein family(sHSP),includingαA-crystallin andαB-crystallin,which have cytoprotection and molecular chaperone functions in various cells and tissues.In recent years,it has been found that retinalα-crystallins are involved in proliferative retinal diseases via regulating angiogenesis and epithelial/endothelial-mesenchymal transition.This article introduces the specific mechanism ofα-crystallins,especiallyαB-crystallin,in regulating the development of proliferative retinal diseases,and its potential clinical application.