补充微量元素对多囊卵巢综合征不孕患者促排效果的临床研究

Clinical study on the effect of trace elements supplementation on ovulation induction in infertile women with polycystic ovary syndrome

目的探讨多囊卵巢综合征(PCOS)不孕患者补充微量元素后的促排卵(促排)效果。方法60例PCOS不孕患者,随机分为实验组和对照组,每组30例。对照组给予去氧孕烯炔雌醇片(商品名:妈富隆)治疗,实验组给予妈富隆联合多维元素片治疗。对比两组治疗前后微量元素水平及性激素指标水平,治疗后的排卵率、妊娠率、流产率。结果治疗后,实验组外周血微量元素铜(Cu)、锌(Zn)、铁(Fe)水平分别为(18.21±2.86)μg/L、(75.89±6.78)mg/L、(8.02±0.72)mg/L,均高于对照组的(7.28±0.62)μg/L、(52.86±4.68)mg/L、(5.61±1.12)mg/L,差异具有统计学意义(P<0.05)。治疗后,两组睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)水平均较本组治疗前改善,差异具有统计学意义(P<0.05)。实验组患者排卵率、妊娠率高于对照组,流产率低于对照组,差异具有统计学意义(P<0.05)。结论微量元素缺乏可能是影响PCOS不孕患者生育功能的重要原因之一,补充微量元素Cu、Zn、Fe可以改善PCOS不孕患者的促排效果,对其助孕治疗有指导意义,值得临床推广。

Objective To discuss the effect of trace elements supplementation on ovulation induction in infertile women with polycystic ovary syndrome(PCOS).Methods A total of 60 infertile women with PCOS were randomly divided into experimental group and control group,with 30 cases in each group.The control group was treated with desogestrel and ethinylestradiol tablets(trade name:Marvelon),and the experimental group was treated with Marvelon combined with multivitamin formula with minerals.The levels of trace elements and sex hormones before and after treatment,ovulation rate,pregnancy rate and abortion rate after treatment were compared between the two groups.Results After treatment,the trace elements copper(Cu),zinc(Zn),iron(Fe)levels in peripheral blood were(18.21±2.86)μg/L,(75.89±6.78)mg/L and(8.02±0.72)mg/L,which were higher than(7.28±0.62)μg/L,(52.86±4.68)mg/L,(5.61±1.12)mg/L of the control group,and the difference was statistically significant(P<0.05).After treatment,testosterone(T),luteinizing hormone(LH),follicle stimulating hormone(FSH)of the two groups were improved than those before treatment,and the difference was statistically significant(P<0.05).The ovulation rate,pregnancy rate of the experimental group were higher than those of the control group,and abortion rate was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The lack of trace elements may be one of the important factors affecting the reproductive function of infertile patients with PCOS.Supplement of trace elements Cu,Zn,Fe can improve the ovulation induction effect of infertile patients with PCOS,which has guiding significance for the treatment of assisted pregnancy,and is worthy of clinical promotion.