不同益生菌对新生儿抗生素相关性腹泻肠道菌群平衡的影响

Effects of different probiotics on the balance of intestinal flora in neonatal antibiotic-associated diarrhea

目的探讨不同益生菌对新生儿抗生素相关性腹泻肠道菌群和血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的影响。方法将78例抗生素相关性腹泻患儿随机分为观察组和对照组,每组39例。对照组口服布拉酵母,观察组口服酪酸梭菌二联活菌散。比较2组临床疗效以及治疗前后肠道菌群数目、血清TNF-α、IL-6水平。结果2组使用抗生素至出现腹泻症状时间差异无统计学意义(P>0.05)。观察组停止腹泻时间、住院时间短于对照组,差异有统计学意义(P<0.05)。2组治疗3 d后粪便中双歧杆菌、真杆菌、乳杆菌数量均高于治疗前,观察组双歧杆菌、真杆菌、乳杆菌数量均高于对照组,差异有统计学意义(P<0.05);2组治疗3 d后血清TNF-α、IL-6水平均低于治疗前,观察组血清TNF-α、IL-6水平均低于对照组,差异有统计学意义(P<0.05)。观察组临床总有效率为89.74%,高于对照组的69.23%,差异有统计学意义(P<0.05)。结论酪酸梭菌二联活菌散治疗抗生素相关性腹泻可有效缩短患儿腹泻、住院时间,显著增加患儿肠道菌群数量,减轻炎性反应。

Objective To investigate the effects of different probiotics on intestinal flora,serum tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6)in neonatal antibiotic-associated diarrhea.Methods A total of 78 children with antibiotic-related diarrhea were randomly divided into observation group and control group,with 39 cases in each group.The control group took Saccharomyces boulardii,and the observation group took Combined Clostridium Butyricum and Bifidobacterium Powders.The diarrhea situation and clinical efficacy were compared between the two groups,and the changes of number of intestinal flora as well as serum TNF-αand IL-6 level before and after treatment were compared.Results There was no significant difference between the two groups in the time from antibiotics to diarrhea(P>0.05).The duration of stopping diarrhea and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05).After 3 days of treatment,the number of bifidobacteria,eubacteriums and lactobacillus in feces of the two groups was significantly higher than those before treatment,while the number of bifidobacteria,eubacteriums and lactobacillus in the observation group was significantly higher than those in the control group(P<0.05);the serum TNF-αand IL-6 levels were significantly lower in the observation group than those in the control group(P<0.05).The total clinical effective rate of the observation group was 89.74%,which was significantly higher than 69.23%of the control group(P<0.05).Conclusion The treatment of antibiotic-associated diarrhea and Combined Clostridium Butyricum and Bifidobacterium Powders can effectively shorten the diarrhea and hospital stay in children,significantly increase the number of intestinal flora and reduce inflammatory response.