哮喘对儿童骨发育的影响研究

Study on effect of asthma on bone development in children

目的探讨哮喘对儿童骨发育的影响。方法选取青岛大学附属医院小儿哮喘专科门诊确诊为轻中度支气管哮喘的80例患儿为研究对象,将其中40例轻度哮喘患儿纳入轻度哮喘组,另外40例中度支气管哮喘患儿纳入中度哮喘组,均接受吸入低剂量的糖皮质激素治疗,同时选取同期体检的30例健康患儿为对照组。检测3组患儿的骨密度(BMD)和血清1,25-二羟维生素D3[1,25-(OH)2D3]水平。结果轻度哮喘组和中度哮喘组BMD值低于对照组,差异有统计学意义(P<0.05);中度哮喘组血清1,25-(OH)2D3水平低于对照组,差异有统计学意义(P<0.05);轻度哮喘组血清1,25-(OH)2D3水平略低于对照组,但差异无统计学意义(P>0.05)。结论未经正规治疗的哮喘对儿童骨质发育有显著影响,且哮喘程度越严重影响越大。

Objective To investigate effect of asthma on bone development in children.Methods A total of 80 children with mild or moderate bronchial asthma diagnosed in pediatric asthma outpatient department of Affiliated Hospital of Qingdao University were selected as the research objects,among whom 40 children diagnosed as mild bronchial asthma children were selected as mild asthma group,another 40 moderate bronchial asthma were selected as moderate asthma group.These children were treated with low dose of glucocorticoid after diagnosis.At the same time,thirty healthy children with physical examinations were selected as control group.Bone mineral density(BMD)and serum1,25-dihydroxyvitamin D3[1,25-(OH)2 D3]of three groups were measured.Results BMD values of mild asthma group and moderate asthma group were lower than those of the control group,and the difference was statistically significant(P<0.05).The serum 1,25-(OH)2 D3 level in the moderate asthma group was significantly lower than that in the control group(P<0.05).The serum 1,25-(OH)2 D3 level in the mild asthma group was slightly lower than that in the control group,but no difference was found(P>0.05).Conclusion Asthma without regular treatment can delay the bone development in children,the severer degree of asthma is,the more effect it will be.