食管癌根除术后合并吻合口漏的影响因素分析

Analysis of the influencing factors of anastomotic leakage after esophageal cancer eradication

目的分析食管癌根除术后合并吻合口漏的影响因素。方法 2016年12月~2018年12月收治的食管癌根治术病人300例,根据是否发生术后吻合口漏分为吻合口漏组(84例)和无吻合口漏组(216例),采用单因素和Logistic回归法分析影响食管癌根除术后发生吻合口漏的因素。结果单因素分析显示,发生吻合口漏的主要影响因素包括手术方式、吻合口位置、术前放化疗、术前血清白蛋白水平、合并呼吸系统疾病和手术时间。Logistic回归分析显示,手术方式、吻合口位置、术前放化疗、合并呼吸系统疾病、手术时间和血清白蛋白水平是引起食管癌根治术后吻合口漏的独立风险因素。结论引起食管癌根治术后吻合口漏的风险因素较多,应针对这些独立风险因素制定有效的预防处理对策。

Objective To explore and analyze the risk factors of anastomotic leakage after esophageal cancer eradication.Methods According to the occurrence of postoperative anastomotic leakage,300 patients underwent esophagectomy in our hospital from December 2016 to December 2018 were divided into anastomotic leakage group(84 cases) and non-anastomotic leakage group(216 cases).Univariate analysis,and logistic regression analysis was used to analyze the risk factors of anastomotic leakage after esophageal cancer eradication.Results Univariate analysis showed that the main influencing factors of anastomotic leakage included operation mode,anastomotic position,preoperative radiotherapy and chemotherapy,serum albumin level,respiratory diseases and operation time.Logistic regression analysis showed that operation mode,anastomotic position,preoperative radiotherapy and chemotherapy,combined with respiratory diseases,operation time and albumin level were independent risk factors of anastomotic leakage after esophagectomy.Conclusion There are many risk factors of anastomotic leakage after radical resection of esophageal cancer.Therefore,effective prevention and treatment measures should be made according to these independent risk factors.