瞬时受体电位通道3与心房颤动

Canonical transient receptor potential 3 and atrial fibrillation

瞬时受体电位通道3(TRPC3)是一种非电压门控非选择性阳离子通道,在心血管系统中广泛分布,特别是在心房成纤维细胞中作为调控Ca2+稳态的关键通道。心房颤动是临床上最常见的快速性心律失常之一,心房结构重构和电重构是其发生的症结所在,纤维化作为结构重构的病理基础,是胶原纤维蓄积所导致。研究证实,TRPC3基因突变或过表达所引起的Ca2+超载,导致心房肌纤维化。因此,TRPC3通道在心房颤动中所起的作用不容忽视。

Transient receptor potential channel 3(TRPC3)is a non-voltage-gated and non-selective cationic channel widely distributed in the cardiovascular system,especially in atrial fibroblasts as a key channel for regulating Ca2+homeostasis.Atrial fibrillation is one of the most common clinical tachyarrhythmias.Atrial structural remodeling and electrical remodeling are the cruces of its occurrence.As the pathological basis of structural remodeling,fibrosis is caused by the accumulation of collagen fibers.Studies have confirmed that Ca2+overload caused by mutation or overexpression of the TRPC3 gene can easily lead to atrial fibrosis.Therefore,the role of TRPC3 channels in atrial fibrillation cannot be ignored.