ASP基因rs2250656位点多态性与新疆汉族及少数民族脂质代谢及冠心病严重程度的相关性研究

Association of ASP gene rs2250656 locus polymorphism with lipid metabolism and severity of coronary heart disease in Xinjiang Han and ethnic minorities

目的:探讨ASP基因rs2250656位点多态性与新疆汉族及少数民族脂质代谢及冠心病严重程度的相关性。方法:纳入新疆地区冠心病患者818例,其中汉族组489例,少数民族组329例。采用SNPscanTM高通量基因分型技术检测所纳入患者基因多态性,并检测血脂水平及冠状动脉(冠脉)病变程度。结果:ASP基因rs2250656位点TT基因型汉族组(61.8%)明显高于少数民族组(52.9%),TC基因型少数民族组(32.9%)明显高于汉族组(41.3%),分布差异有统计学意义(P<0.05),两组等位基因T与C频率分布差异有统计学意义(P<0.05)。少数民族组基因型亚组间的甘油三酯水平差异有统计学意义(P<0.05),其中CC基因型甘油三酯水平明显高于TT基因型及TC基因型;少数民族组基因型亚组间的冠脉病变程度差异有统计学意义(P<0.05),其中CC基因型病变严重程度高于TT基因型及TC基因型。结论:ASP基因rs2250656位点C等位基因与少数民族冠心病患者甘油三酯增高有一定相关性,CC基因型可能是少数民族冠心病的危险因素之一,而其与汉族冠心病的发病可能无一定的关联性。

Objective:To explore the association among ASP gene rs2250656 locus polymorphism,lipid metabolism and the severity of coronary heart disease in the Han and minorities in Xinjiang.Method:Eight hundred and eighteen patients with coronary heart disease in Xinjiang were included,in which 489 in the Han group and 329 in the minority group.Gene polymorphisms were detected by SNPscanTM high-throughput genotyping technology.Blood lipid levels and coronary lesions were tested.Result:ASP gene rs2250656 locus TT genotype in the Han group(61.8%)was significantly higher than that in the minority group(52.9%),TC genotype in the minority group(32.9%)was significantly higher than that in the Han group(41.3%),the distribution difference was statistical significant(P<0.05),and there was a significant difference in the frequency distribution of alleles T and C between the two groups(P<0.05).The difference in triglyceride levels among genotype subgroups in the minority group was statistically significant(P<0.05),the triglyceride level in the CC genotype was significantly higher than those in the TT genotype and TC genotype.The difference in the degree of coronary artery disease among genotype subgroups in the minority group was statistically significant(P<0.05),the severity of coronary artery disease in the CC genotype was significantly higher than those in the TT genotype and TC genotype.Conclusion:The C allele of the rs2250656 locus of the ASP gene is associated with an increased triglyceride level in patients with coronary heart disease in ethnic minorities.The CC genotype may be one of the risk factors for coronary heart disease in ethnic minorities,while it may not be a specific correlation with coronary heart disease in Han nationality.