摘要
越来越多的证据表明脑源性神经营养因子(EDNF)对阿尔茨海默病的(AD)的认知功能具有十分重要的作用,尤其是BDNFVal66Met基因多态性,诸多研究证实其影响认知功能。本文通过综述BDNF及其Val66Met基因多态性对AD的临床应用,旨在探讨二者对AD的应用价值及影响。
Increasing evidence indicates that brain-derived neurotrophic factor(BDNF),especially its BDNFVal66Met gene polymorphism,plays an important role in cognitive function of Alzheimer's disease(AD),with its effects on cognition function confirmed by a large number of studies.Therefore,this article reviews the clinical application of BDNF and BDNFVal66Met for Alzheimer's disease(AD),aiming to examine their practical value and effects on AD.
作者
郝立晓
贾建国
张仲迎
韩璎
Hao Lixiao;Jia Jianguo;Zhang Zhongying;Han Ying(department of General Practice,Xuanivu Hospital of Capital Medical University,Beijing 100053,China;Department of General Surgery,Xuanivu Hospital of Capital Medical University,Beijingl00053,China;Department of Geriatrics,Xuanivu Hospital of Capital Medical University,Beijing 100053,China;Department of Neurology,Xuanivu Hospital of Capital Medical University,Beijing 100053,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2020年第11期1346-1349,共4页
Chinese Journal of Geriatrics
基金
国家自然科学基金项目(61633018)
首都医科大学宣武医院院级课题(XWJL-2019014)。
关键词
脑源性神经营养因子
基因多态性
阿尔茨海默病
Brain-derived neurotrophic factor
Genetic polymorphism
Alzheimer's disease
