双相情感障碍子代认知功能损害的研究进展

Research progress of cognitive impairment in offspring with bipolar disorder

目前普遍认为双相情感障碍子代是患双相情感障碍的高危人群,存在不同程度的认知功能损害,其机制可能与遗传、生物学等因素相关,但尚未明确。这些认知损害并非是单一因素所造成的,其损害机制可能与基因多态性、免疫炎症、大脑结构等多方面因素相关。现对双相情感障碍子代存在的认知损害及可能的机制研究进行综述。

At present,it is generally believed that offspring of bipolar disorder(BDoff)is a high-risk population with bipolar disorder.Studies have shown that BDoff suffer from cognitive impairment to varying degrees,and the mechanism may be related to genetic and biological factors,but it has not been clarified.These cognitive impairment is not caused by single factor,as the damage mechanism may be related to gene polymorphism,immune inflammation,the brain structure,etc.This paper reviews the cognitive impairment and its possible mechanism in the BDoff.