生姜联合托烷司琼对乳腺癌化疗相关性恶心呕吐的疗效

Curative effects of ginger combined with tropisetron on chemotherapy-induced nausea and vomiting of breast cancer

目的探讨生姜联合托烷司琼预防乳腺癌患者化疗致恶心呕吐的疗效。方法采用便利抽样法,选取北京天坛医院2019年4—12月收治的乳腺癌首次化疗患者80例,采用随机数字表法将患者分为对照组和干预组,每组40例。对照组常规化疗前静脉使用托烷司琼预防恶心、呕吐,干预组在此基础上,化疗前30 min舌下含服薄片新鲜生姜片,另用生姜薄片贴敷于患者的神阙穴及内关穴,比较两组患者化疗后恶心、呕吐程度以及化疗依从性。结果化疗后0~5 d,干预组发生Ⅱ~Ⅲ级恶心患者7例,对照组18例;干预组发生Ⅱ~Ⅲ级呕吐患者4例,对照组18例;两组恶心、呕吐程度比较,差异有统计学意义(Z值分别为-2.980、-4.151;P<0.05)。两组化疗依从性比较,差异无统计学意义(P>0.05)。结论口含生姜及生姜穴位敷贴联合托烷司琼可有效缓解患者化疗相关性恶心呕吐症状。

Objective To explore the curative effect of ginger combined with tropisetron on preventing nausea and vomiting caused by chemotherapy in patients with breast cancer.Methods 80 patients with breast cancer who received first chemotherapy from Beijing Tiantan Hospital from April 2019 to December 2019 were selected by the convenient sampling method.According to the random number table method,they were divided into the control group and the intervention group,with 40 cases in each group.The control group received intravenous tropisetron before routine chemotherapy to prevent nausea and vomiting.On this basis,patients in the intervention group took slices of fresh ginger under the tongue 30 min before chemotherapy and applied the slices of fresh ginger to Shenque acupoint and Neiguan acupoint.The degree of nausea and vomiting after chemotherapy and compliance with chemotherapy were compared between the two groups.Results On 0 to 5 d after chemotherapy,there were 7 patients with nausea of gradeⅡandⅢin the intervention group and 18 patients with nausea of gradeⅡandⅢin the control group.There were 4 patients with vomiting of gradeⅡandⅢin the intervention group and 18 patients with vomiting of gradeⅡandⅢin the control group.There were statistically significant differences in the degrees of nausea and vomiting between the two groups(Z=-2.980,-4.151;P<0.05).There was no statistically significant difference in chemotherapy compliance between the two groups(P>0.05).Conclusions Ginger in mouth and ginger point application combined with tropisetron can effectively alleviate chemotherapy-induced nausea and vomiting symptoms.